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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Influenza A Virus, H2N2 Subtype

 
 
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High impact information on Influenza A Virus, H2N2 Subtype

  • Immune sera from H1N1-infected mice augmented uptake of the homologous (H1N1) and H2N2 viruses [1].
  • The haemagglutinin (HA) of influenza A/H2N2 virus possesses six antigenic sites (I-A to I-D, II-A and II-B), and sites I-A, I-B and I-C are located in the regions corresponding to sites A, B and D on the H3 HA [2].
  • The data presented in this report show that vaccination with a highly purified recombinant influenza protein antigen in aluminium hydroxide adjuvant, the only adjuvant currently licensed for clinical use, elicited class I restricted CTL and protection from lethal challenge with H1N1 and H2N2 viruses [3].
  • Azetidines 5 and 6 were both markedly active against influenza A H2N2 virus, 10- to 20-fold more potent than amantadine [4].
  • Aziridine 7 was almost devoid of any activity against H2N2 virus but exhibited borderline activity against H3N2 influenza A strain [4].
 

Chemical compound and disease context of Influenza A Virus, H2N2 Subtype

  • Subunits released from influenza A/Singapore/1/57 (H2N2) virus by either Triton-X-100 (T-X-100); or sodium lauryl sarcosinate (SLS) or ether were separated by electrophoresis in agarose suspension into a rapidly migrating fraction (I) and a slowly migrating fraction (II) [5].

References

  1. Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses. Tamura, M., Webster, R.G., Ennis, F.A. J. Virol. (1994) [Pubmed]
  2. Effect of addition of new oligosaccharide chains to the globular head of influenza A/H2N2 virus haemagglutinin on the intracellular transport and biological activities of the molecule. Tsuchiya, E., Sugawara, K., Hongo, S., Matsuzaki, Y., Muraki, Y., Li, Z.N., Nakamura, K. J. Gen. Virol. (2002) [Pubmed]
  3. Induction of protective class I MHC-restricted CTL in mice by a recombinant influenza vaccine in aluminium hydroxide adjuvant. Dillon, S.B., Demuth, S.G., Schneider, M.A., Weston, C.B., Jones, C.S., Young, J.F., Scott, M., Bhatnaghar, P.K., LoCastro, S., Hanna, N. Vaccine (1992) [Pubmed]
  4. Heterocyclic rimantadine analogues with antiviral activity. Zoidis, G., Fytas, C., Papanastasiou, I., Foscolos, G.B., Fytas, G., Padalko, E., De Clercq, E., Naesens, L., Neyts, J., Kolocouris, N. Bioorg. Med. Chem. (2006) [Pubmed]
  5. Electrophoretic separation and characterization of subunits released from influenza virus by detergents. Russ, G., Ruttkay-Nedecky, G., Mucha, V. Acta Virol. (1976) [Pubmed]
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