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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Urinary Bladder Neoplasms

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Gene context of Urinary Bladder Neoplasms

  • The best predictors of bladder cancer included the XPD codon 751 and 312 SNPs along with smoking [1].
  • Ever smokers with the MMP12 G allele also had an increased risk of bladder cancer invasiveness (OR, 2.32; 95% CI, 1.30-4.12) [2].
  • An SNP polymorphism in the non-protein-encoding H19 gene is associated with a decreased risk of developing non-muscle-invasive bladder cancer [3].


  1. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Andrew, A.S., Nelson, H.H., Kelsey, K.T., Moore, J.H., Meng, A.C., Casella, D.P., Tosteson, T.D., Schned, A.R., Karagas, M.R. Carcinogenesis (2006) [Pubmed]
  2. Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness. Kader, A.K., Liu, J., Shao, L., Dinney, C.P., Lin, J., Wang, Y., Gu, J., Grossman, H.B., Wu, X. Clin. Cancer Res. (2007) [Pubmed]
  3. Polymorphisms in the H19 gene and the risk of bladder cancer. Verhaegh, G.W., Verkleij, L., Vermeulen, S.H., den Heijer, M., Witjes, J.A., Kiemeney, L.A. Eur. Urol. (2008) [Pubmed]
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