Gene Review:
MMP12 - matrix metallopeptidase 12 (macrophage...
Homo sapiens
Synonyms:
HME, ME, MME, MMP-12, Macrophage elastase, ...
Matsumoto,
Kobayashi,
Katoh,
Saito,
Ikeda,
Kobori,
Masuho,
Watanabe,
Zucker,
Vacirca,
Vazquez-Ortiz,
Pina-Sanchez,
Vazquez,
Duenas,
Taja,
Mendoza,
Garcia,
Salcedo,
Wallace,
Sandford,
Plantner,
Smine,
Quinn,
Xie,
Issa,
Sukkar,
Oltmanns,
Bhavsar,
Papi,
Caramori,
Adcock,
Chung,
Shin,
Cai,
Shu,
Gao,
Zheng,
Ikonomidis,
Jones,
Barbour,
Stroud,
Clark,
Kaplan,
Zeeshan,
Bavaria,
Gorman,
Spinale,
Gorman,
Belaaouaj,
Li,
Wun,
Welgus,
Shapiro,
Demedts,
Morel-Montero,
Lebecque,
Pacheco,
Cataldo,
Joos,
Pauwels,
Brusselle,
Mecham,
Broekelmann,
Fliszar,
Shapiro,
Welgus,
Senior,
- Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease. Cawston, T., Carrere, S., Catterall, J., Duggleby, R., Elliott, S., Shingleton, B., Rowan, A. Novartis Found. Symp. (2001)
- Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. Shapiro, S.D., Kobayashi, D.K., Ley, T.J. J. Biol. Chem. (1993)
- MMP expression profiling in recurred stage IB lung cancer. Cho, N.H., Hong, K.P., Hong, S.H., Kang, S., Chung, K.Y., Cho, S.H. Oncogene (2004)
- Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. Lang, R., Kocourek, A., Braun, M., Tschesche, H., Huber, R., Bode, W., Maskos, K. J. Mol. Biol. (2001)
- Role of matrix metalloproteinases (MMPs) in colorectal cancer. Zucker, S., Vacirca, J. Cancer Metastasis Rev. (2004)
- Wireless CPAP patient monitoring: accuracy study. Lankford, D.A. Telemedicine journal and e-health : the official journal of the American Telemedicine Association. (2004)
- Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages. Werb, Z., Banda, M.J., Jones, P.A. J. Exp. Med. (1980)
- Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor. Banda, M.J., Clark, E.J., Werb, Z. J. Exp. Med. (1980)
- Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. Curci, J.A., Liao, S., Huffman, M.D., Shapiro, S.D., Thompson, R.W. J. Clin. Invest. (1998)
- Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study. Shin, A., Cai, Q., Shu, X.O., Gao, Y.T., Zheng, W. Breast Cancer Res. (2005)
- The effects of harmaline on sodium transport in human erythrocytes: evidence in favor of action at interior sodium-sensitive sites. Dunn, M.J., Hunt, W. J. Pharmacol. Exp. Ther. (1975)
- Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrix. Wu, T.H., Yang, R.L., Xie, L.P., Wang, H.Z., Chen, L., Zhang, S., Zhao, Y., Zhang, R.Q. Cancer Lett. (2006)
- Comparison of three different humidification systems during prolonged mechanical ventilation. Luchetti, M., Stuani, A., Castelli, G., Marraro, G. Minerva anestesiologica. (1998)
- The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Joos, L., He, J.Q., Shepherdson, M.B., Connett, J.E., Anthonisen, N.R., Paré, P.D., Sandford, A.J. Hum. Mol. Genet. (2002)
- Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line. Kamochi, J., Tokunaga, T., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M. Oncol. Rep. (2003)
- Genetic polymorphisms of matrix metalloproteinases: functional importance in the development of chronic obstructive pulmonary disease? Wallace, A.M., Sandford, A.J. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. (2002)
- Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis. Mecham, R.P., Broekelmann, T.J., Fliszar, C.J., Shapiro, S.D., Welgus, H.G., Senior, R.M. J. Biol. Chem. (1997)
- Migration of monocytes/macrophages in vitro and in vivo is accompanied by MMP12-dependent tunnel formation and by neovascularization. Anghelina, M., Schmeisser, A., Krishnan, P., Moldovan, L., Strasser, R.H., Moldovan, N.I. Cold Spring Harb. Symp. Quant. Biol. (2002)
- Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development. Matsumoto, S., Kobayashi, T., Katoh, M., Saito, S., Ikeda, Y., Kobori, M., Masuho, Y., Watanabe, T. Am. J. Pathol. (1998)
- Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Xie, S., Issa, R., Sukkar, M.B., Oltmanns, U., Bhavsar, P.K., Papi, A., Caramori, G., Adcock, I., Chung, K.F. Respir. Res. (2005)
- Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation. Belaaouaj, A.A., Li, A., Wun, T.C., Welgus, H.G., Shapiro, S.D. J. Biol. Chem. (2000)
- Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome. Kerkelä, E., Ala-aho, R., Klemi, P., Grénman, S., Shapiro, S.D., Kähäri, V.M., Saarialho-Kere, U. J. Pathol. (2002)
- Elevated MMP-12 protein levels in induced sputum from patients with COPD. Demedts, I.K., Morel-Montero, A., Lebecque, S., Pacheco, Y., Cataldo, D., Joos, G.F., Pauwels, R.A., Brusselle, G.G. Thorax (2006)
- Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Sarkar, S., Nuttall, R.K., Liu, S., Edwards, D.R., Yong, V.W. Cancer Res. (2006)
- Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation. Kerkelä, E., Böhling, T., Herva, R., Uria, J.A., Saarialho-Kere, U. Bone (2001)
- Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII. Hiller, O., Lichte, A., Oberpichler, A., Kocourek, A., Tschesche, H. J. Biol. Chem. (2000)
- Heat modulation of tropoelastin, fibrillin-1, and matrix metalloproteinase-12 in human skin in vivo. Chen, Z., Seo, J.Y., Kim, Y.K., Lee, S.R., Kim, K.H., Cho, K.H., Eun, H.C., Chung, J.H. J. Invest. Dermatol. (2005)
- Matrix metalloproteinases and metalloproteinase inhibitors in human interphotoreceptor matrix and vitreous. Plantner, J.J., Smine, A., Quinn, T.A. Curr. Eye Res. (1998)
- Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis, J.S., Jones, J.A., Barbour, J.R., Stroud, R.E., Clark, L.L., Kaplan, B.S., Zeeshan, A., Bavaria, J.E., Gorman, J.H., Spinale, F.G., Gorman, R.C. Circulation (2006)
- Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. Vazquez-Ortiz, G., Pina-Sanchez, P., Vazquez, K., Duenas, A., Taja, L., Mendoza, P., Garcia, J.A., Salcedo, M. BMC Cancer (2005)