Gene Review:
ERCC2 - excision repair cross-complementation group 2
Homo sapiens
Synonyms:
BTF2 p80, Basic transcription factor 2 80 kDa subunit, COFS2, CXPD, DNA excision repair protein ERCC-2, ...
Chen,
Malapetsa,
Monks,
Myers,
Mohr,
Sausville,
Scudiero,
Panasci,
Millikan,
Hummer,
Begg,
Player,
de Cotret,
Winkel,
Mohrenweiser,
Thomas,
Armstrong,
Kricker,
Marrett,
Gruber,
Culver,
Zanetti,
Gallagher,
Dwyer,
Rebbeck,
Busam,
From,
Mujumdar,
Berwick,
Chen,
Zhang,
Mohr,
Ishikawa,
Yamamoto,
Tian,
Kawano,
Yamauchi,
Yokoyama,
Shen,
Berndt,
Rothman,
Demarini,
Mumford,
He,
Bonner,
Tian,
Yeager,
Welch,
Chanock,
Zheng,
Caporaso,
Lan,
Pavanello,
Pulliero,
Siwinska,
Mielzynska,
Clonfero,
Broberg,
Björk,
Paulsson,
Höglund,
Albin,
- The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. Schaeffer, L., Moncollin, V., Roy, R., Staub, A., Mezzina, M., Sarasin, A., Weeda, G., Hoeijmakers, J.H., Egly, J.M. EMBO J. (1994)
- Chromosome 19q deletions in human gliomas overlap telomeric to D19S219 and may target a 425 kb region centromeric to D19S112. Yong, W.H., Chou, D., Ueki, K., Harsh, G.R., von Deimling, A., Gusella, J.F., Mohrenweiser, H.W., Louis, D.N. J. Neuropathol. Exp. Neurol. (1995)
- Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Damaraju, S., Murray, D., Dufour, J., Carandang, D., Myrehaug, S., Fallone, G., Field, C., Greiner, R., Hanson, J., Cass, C.E., Parliament, M. Clin. Cancer Res. (2006)
- Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China. Shen, M., Berndt, S.I., Rothman, N., Demarini, D.M., Mumford, J.L., He, X., Bonner, M.R., Tian, L., Yeager, M., Welch, R., Chanock, S., Zheng, T., Caporaso, N., Lan, Q. Int. J. Cancer (2005)
- XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Manuguerra, M., Saletta, F., Karagas, M.R., Berwick, M., Veglia, F., Vineis, P., Matullo, G. Am. J. Epidemiol. (2006)
- A role of the C-terminal part of p44 in the promoter escape activity of transcription factor IIH. Tremeau-Bravard, A., Perez, C., Egly, J.M. J. Biol. Chem. (2001)
- Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers. Pavanello, S., Pulliero, A., Siwinska, E., Mielzynska, D., Clonfero, E. Carcinogenesis (2005)
- Lethality in yeast of trichothiodystrophy (TTD) mutations in the human xeroderma pigmentosum group D gene. Implications for transcriptional defect in TTD. Guzder, S.N., Sung, P., Prakash, S., Prakash, L. J. Biol. Chem. (1995)
- Correlates of delayed referral for the diagnosis of dementia in an outpatient population. Cattel, C., Gambassi, G., Sgadari, A., Zuccalà, G., Carbonin, P., Bernabei, R. J. Gerontol. A Biol. Sci. Med. Sci. (2000)
- Myocardial and peripheral vascular functional adaptation to exercise training. Hannukainen, J.C., Janatuinen, T., Toikka, J.O., Järvisalo, M.J., Heinonen, O.J., Kapanen, J., Någren, K., Nuutila, P., Kujala, U.M., Kaprio, J., Knuuti, J., Kalliokoski, K.K. Scandinavian journal of medicine & science in sports (2007)
- A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Giglia-Mari, G., Coin, F., Ranish, J.A., Hoogstraten, D., Theil, A., Wijgers, N., Jaspers, N.G., Raams, A., Argentini, M., van der Spek, P.J., Botta, E., Stefanini, M., Egly, J.M., Aebersold, R., Hoeijmakers, J.H., Vermeulen, W. Nat. Genet. (2004)
- XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha. Keriel, A., Stary, A., Sarasin, A., Rochette-Egly, C., Egly, J.M. Cell (2002)
- Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study. Millikan, R.C., Hummer, A., Begg, C., Player, J., de Cotret, A.R., Winkel, S., Mohrenweiser, H., Thomas, N., Armstrong, B., Kricker, A., Marrett, L.D., Gruber, S.B., Culver, H.A., Zanetti, R., Gallagher, R.P., Dwyer, T., Rebbeck, T.R., Busam, K., From, L., Mujumdar, U., Berwick, M. Carcinogenesis (2006)
- Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD. Aloyz, R., Xu, Z.Y., Bello, V., Bergeron, J., Han, F.Y., Yan, Y., Malapetsa, A., Alaoui-Jamali, M.A., Duncan, A.M., Panasci, L. Cancer Res. (2002)
- Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Banerjee, M., Sarkar, J., Das, J.K., Mukherjee, A., Sarkar, A.K., Mondal, L., Giri, A.K. Carcinogenesis (2007)
- Enhancing alkylating agent resistance through ERCC2 gene transfection in human glioma cell line. Chen, Z., Zhang, J., Mohr, G. Chin. Med. J. (2003)
- A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC1 and ERCC2 genes. Smeets, H., Bachinski, L., Coerwinkel, M., Schepens, J., Hoeijmakers, J., van Duin, M., Grzeschik, K.H., Weber, C.A., de Jong, P., Siciliano, M.J. Am. J. Hum. Genet. (1990)
- Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. Qiao, Y., Spitz, M.R., Shen, H., Guo, Z., Shete, S., Hedayati, M., Grossman, L., Mohrenweiser, H., Wei, Q. Carcinogenesis (2002)
- Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Lamerdin, J.E., Stilwagen, S.A., Ramirez, M.H., Stubbs, L., Carrano, A.V. Genomics (1996)
- Expression of excision repair genes in non-malignant bone marrow from cancer patients. Dabholkar, M., Bostick-Bruton, F., Weber, C., Egwuagu, C., Bohr, V.A., Reed, E. Mutat. Res. (1993)
- Associations between XRCC1 and ERCC2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers. Leng, S., Cheng, J., Pan, Z., Huang, C., Niu, Y., Dai, Y., Li, B., He, F., Zheng, Y. Biomarkers (2004)
- The DNA repair genes XPB and XPD defend cells from retroviral infection. Yoder, K., Sarasin, A., Kraemer, K., McIlhatton, M., Bushman, F., Fishel, R. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. Jaitovich-Groisman, I., Benlimame, N., Slagle, B.L., Perez, M.H., Alpert, L., Song, D.J., Fotouhi-Ardakani, N., Galipeau, J., Alaoui-Jamali, M.A. J. Biol. Chem. (2001)
- 8-Oxoguanine DNA Glycosylase and MutY Homolog Are Involved in the Incision of Arsenite-Induced DNA Adducts. Pu, Y.S., Jan, K.Y., Wang, T.C., Wang, A.S., Gurr, J.R. Toxicol. Sci. (2007)
- Proficient deoxyribonucleic acid repair of methylation damage in hamster ERCC-gene mutants. Nexø, B.A., Dybdahl, M., Damgaard, J., Olsen, L.S., Møller, P., Wassermann, K. Mutat. Res. (1998)
- Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs. Andersson, B.S., Sadeghi, T., Siciliano, M.J., Legerski, R., Murray, D. Cancer Chemother. Pharmacol. (1996)
- Nucleotide excision repair protein levels vis-à-vis anticancer drug resistance in 60 human tumor cell lines. Chen, Z.P., Malapetsa, A., Monks, A., Myers, T.G., Mohr, G., Sausville, E.A., Scudiero, D.A., Panasci, L.C. Ai Zheng (2002)
- Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. Ishikawa, H., Yamamoto, H., Tian, Y., Kawano, M., Yamauchi, T., Yokoyama, K. Mutat. Res. (2003)
- Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Reardon, J.T., Ge, H., Gibbs, E., Sancar, A., Hurwitz, J., Pan, Z.Q. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Saleh-Gohari, N., Bryant, H.E., Schultz, N., Parker, K.M., Cassel, T.N., Helleday, T. Mol. Cell. Biol. (2005)
- Altered DNA ligase III activity in the CHO EM9 mutant. Ljungquist, S., Kenne, K., Olsson, L., Sandström, M. Mutat. Res. (1994)
- The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Wang, X.W., Vermeulen, W., Coursen, J.D., Gibson, M., Lupold, S.E., Forrester, K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J.H., Harris, C.C. Genes Dev. (1996)
- Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Broberg, K., Björk, J., Paulsson, K., Höglund, M., Albin, M. Carcinogenesis (2005)
- Genotyping of patients with sporadic and radiation-associated meningiomas. Sadetzki, S., Flint-Richter, P., Starinsky, S., Novikov, I., Lerman, Y., Goldman, B., Friedman, E. Cancer Epidemiol. Biomarkers Prev. (2005)
- Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. Hu, Z., Xu, L., Shao, M., Yuan, J., Wang, Y., Wang, F., Yuan, W., Qian, J., Ma, H., Wang, Y., Liu, H., Chen, W., Yang, L., Jing, G., Huo, X., Chen, F., Jin, L., Wei, Q., Wu, T., Lu, D., Huang, W., Shen, H. Cancer Epidemiol. Biomarkers Prev. (2006)
- Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19. Thompson, L.H., Bachinski, L.L., Stallings, R.L., Dolf, G., Weber, C.A., Westerveld, A., Siciliano, M.J. Genomics (1989)