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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genes regulating MHC class I processing of antigen.

The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing.[1]


  1. Genes regulating MHC class I processing of antigen. van Endert, P.M. Curr. Opin. Immunol. (1999) [Pubmed]
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