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Gene Review

Tapbp  -  TAP binding protein

Mus musculus

Synonyms: D17Wsu91e, TAP-associated protein, TAP-binding protein, TPN, TPSN, ...
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Disease relevance of Tapbp

  • However, prolonged ischemia (30 minutes) eliminated any benefits of intragastric TPN on survival [1].
  • Intragastric (IG) TPN maintains antiviral defenses but only partially preserves protection against Pseudomonas pneumonia [2].
  • BACKGROUND: Addition of 2% glutamine (GLN), a specific lymphocyte fuel, prevents deleterious effects of TPN on gut-associated lymphoid tissue and IgA while preserving IgA-mediated upper respiratory immunity to influenza virus [3].

High impact information on Tapbp


Biological context of Tapbp


Anatomical context of Tapbp


Associations of Tapbp with chemical compounds

  • The loading of MHC class I molecules with peptides involves a variety of accessory proteins, including TAP-associated glycoprotein (tapasin), which tethers empty MHC class I molecules to the TAP peptide transporter [12].
  • Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-gamma-inducible class I MHC complexes in transformed fibroblast cell lines are regulated by tapasin [14].
  • In this study, we have assessed the influence of a conserved lysine at position 408, which lies in the tapasin transmembrane/cytoplasmic domain [15].
  • The region is also organised differently from mammals, with the TAPs in between the class I genes, the tapasin gene in between the class II (B-L) beta genes, and the C4 gene outside of the class I alpha and class II beta genes [16].
  • In addition to affecting TAP interaction with tapasin, the substitution of alanine, but not tryptophan, for the lysine at tapasin position 408 increased the amount of tapasin found in association with the open, peptide-free form of the HLA-B8 H chain [15].

Physical interactions of Tapbp

  • Furthermore, the IRF-1/2 binding site is required for gamma interferon inducibility of the tapasin promoter in vitro, but also negatively interferes with its constitutive activity [17].
  • Furthermore, K3 is detected predominantly in association with class I molecules lacking assembly with high-affinity peptides, including class I molecules associated with the peptide loading complex TAP/tapasin/calreticulin [18].

Regulatory relationships of Tapbp

  • Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers [19].
  • Cell surface expression of these TAP-independent class I complexes is modulated by tapasin levels and is enhanced by IFN-gamma [14].

Other interactions of Tapbp


Analytical, diagnostic and therapeutic context of Tapbp

  • SUMMARY BACKGROUND DATA: Enteral feeding significantly reduces the incidence of pneumonia in critically injured patients compared with intravenous total parenteral nutrition (IV TPN) or no nutritional support [2].
  • In experiment 3, albumin leak was tested in the complex enteral diet group (n = 5) and the intragastric TPN group (n = 5) after 30 minutes of gut ischemia and 1 hour of reperfusion [1].
  • Tumor weight and DNA synthesis were decreased in the TPN group compared to CASEIN, and host weight increased by 4.6% [23].
  • From Day 14 through 22 postimplant, mice were fed by continuous intravenous infusion of dextrose/amino acid (TPN), were offered the same solution from a feeding bottle (PO), were offered a casein-based, solid diet (CASEIN), or were infused with an electrolyte (ELECT) solution while energy and nitrogen were provided from the casein diet [23].


  1. Enteral nutrition prevents remote organ injury and death after a gut ischemic insult. Fukatsu, K., Zarzaur, B.L., Johnson, C.D., Lundberg, A.H., Wilcox, H.G., Kudsk, K.A. Ann. Surg. (2001) [Pubmed]
  2. Route and type of nutrition influence IgA-mediating intestinal cytokines. Wu, Y., Kudsk, K.A., DeWitt, R.C., Tolley, E.A., Li, J. Ann. Surg. (1999) [Pubmed]
  3. Glutamine-enriched total parenteral nutrition preserves respiratory immunity and improves survival to a Pseudomonas Pneumonia. DeWitt, R.C., Wu, Y., Renegar, K.B., Kudsk, K.A. J. Surg. Res. (1999) [Pubmed]
  4. Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. van Hall, T., Wolpert, E.Z., van Veelen, P., Laban, S., van der Veer, M., Roseboom, M., Bres, S., Grufman, P., de Ru, A., Meiring, H., de Jong, A., Franken, K., Teixeira, A., Valentijn, R., Drijfhout, J.W., Koning, F., Camps, M., Ossendorp, F., Kärre, K., Ljunggren, H.G., Melief, C.J., Offringa, R. Nat. Med. (2006) [Pubmed]
  5. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Grandea, A.G., Golovina, T.N., Hamilton, S.E., Sriram, V., Spies, T., Brutkiewicz, R.R., Harty, J.T., Eisenlohr, L.C., Van Kaer, L. Immunity (2000) [Pubmed]
  6. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Garbi, N., Tan, P., Diehl, A.D., Chambers, B.J., Ljunggren, H.G., Momburg, F., Hämmerling, G.J. Nat. Immunol. (2000) [Pubmed]
  7. Multiple Residues in the Transmembrane Helix and Connecting Peptide of Mouse Tapasin Stabilize the Transporter Associated with the Antigen-processing TAP2 Subunit. Papadopoulos, M., Momburg, F. J. Biol. Chem. (2007) [Pubmed]
  8. Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing. Li, S., Paulsson, K.M., Sjögren, H.O., Wang, P. J. Biol. Chem. (1999) [Pubmed]
  9. An extensive region of an MHC class I alpha 2 domain loop influences interaction with the assembly complex. Yu, Y.Y., Turnquist, H.R., Myers, N.B., Balendiran, G.K., Hansen, T.H., Solheim, J.C. J. Immunol. (1999) [Pubmed]
  10. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Herberg, J.A., Sgouros, J., Jones, T., Copeman, J., Humphray, S.J., Sheer, D., Cresswell, P., Beck, S., Trowsdale, J. Eur. J. Immunol. (1998) [Pubmed]
  11. Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. Chefalo, P.J., Grandea, A.G., Van Kaer, L., Harding, C.V. J. Immunol. (2003) [Pubmed]
  12. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. Li, L., Sullivan, B.A., Aldrich, C.J., Soloski, M.J., Forman, J., Grandea, A.G., Jensen, P.E., Van Kaer, L. J. Immunol. (2004) [Pubmed]
  13. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. Chen, M., Tabaczewski, P., Truscott, S.M., Van Kaer, L., Stroynowski, I. J. Immunol. (2005) [Pubmed]
  14. Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-gamma-inducible class I MHC complexes in transformed fibroblast cell lines are regulated by tapasin. Fromm, S.V., Duady-Ben Yaakov, S., Schechter, C., Ehrlich, R. Cell. Immunol. (2002) [Pubmed]
  15. A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation. Petersen, J.L., Hickman-Miller, H.D., McIlhaney, M.M., Vargas, S.E., Purcell, A.W., Hildebrand, W.H., Solheim, J.C. J. Immunol. (2005) [Pubmed]
  16. Gene organisation determines evolution of function in the chicken MHC. Kaufman, J., Jacob, J., Shaw, I., Walker, B., Milne, S., Beck, S., Salomonsen, J. Immunol. Rev. (1999) [Pubmed]
  17. Cloning and functional analyses of the mouse tapasin promoter. Herrmann, F., Trowsdale, J., Huber, C., Seliger, B. Immunogenetics (2003) [Pubmed]
  18. Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and beta(2)-microglobulin assembly. Yu, Y.Y., Harris, M.R., Lybarger, L., Kimpler, L.A., Myers, N.B., Virgin, H.W., Hansen, T.H. J. Virol. (2002) [Pubmed]
  19. Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers. Lybarger, L., Yu, Y.Y., Chun, T., Wang, C.R., Grandea, A.G., Van Kaer, L., Hansen, T.H. J. Immunol. (2001) [Pubmed]
  20. Genes regulating MHC class I processing of antigen. van Endert, P.M. Curr. Opin. Immunol. (1999) [Pubmed]
  21. Mutant MHC class I molecules define interactions between components of the peptide-loading complex. Paquet, M.E., Williams, D.B. Int. Immunol. (2002) [Pubmed]
  22. Impaired expression of MHC class I molecules on mouse testicular germ cells is mainly caused by the post-transcriptional mechanism. Hotta, C., Nagata, T., Nakazawa, M., Fujimaki, H., Yoshinari, M., Minami, M. Immunogenetics (2000) [Pubmed]
  23. Decreased lung metastasis and tumor growth in parenterally fed mice. Mahaffey, S.M., Copeland, E.M., Economides, E., Talbert, J.L., Baumgartner, T.G., Sitren, H.S. J. Surg. Res. (1987) [Pubmed]
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