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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Quality Control

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Disease relevance of Quality Control

  • Aberrant folding and defective trafficking of CFTRDeltaF508 is the principal cause of cystic fibrosis, but how the endoplasmic-reticulum quality-control system targets CFTR for degradation remains unknown [1].
  • E. coli has a system of protein quality control surveillance mediated by the ssrA-encoded peptide tagging system [2].
  • The FtsH protease slr0228 is important for quality control of photosystem II in the thylakoid membrane of Synechocystis sp. PCC 6803 [3].
  • Our results suggest that the exclusion of proteins by the ER quality control system, crosstalk between the EGF- and INF-induced signalling pathways and the regulation of INF-inducible genes are all altered in the prostate cancer cells [4].
  • When performing susceptibility testing with H. influenzae with the beta-lactam-beta-lactamase inhibitors, in addition to quality control testing with H. influenzae ATCC 49247, testing of E. coli ATCC 35218 on Haemophilus test medium is an effective way to monitor the beta-lactamase inhibitors in some antimicrobial agent-methodology combinations [5].

Psychiatry related information on Quality Control


High impact information on Quality Control

  • It has become evident that the modifications that take place in the ER reflect a spectrum of functions related to glycoprotein folding, quality control, sorting, degradation, and secretion [8].
  • Loss of SAN1 results in a chronic stress response, underscoring its role of protein quality control in the cell [9].
  • Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways [10].
  • The Ro 60 kDa autoantigen binds misfolded RNAs and likely functions in small RNA quality control [11].
  • AAA proteases comprise a conserved family of membrane bound ATP-dependent proteases that ensures the quality control of mitochondrial inner-membrane proteins [12].

Chemical compound and disease context of Quality Control


Biological context of Quality Control


Anatomical context of Quality Control


Associations of Quality Control with chemical compounds

  • Consideration of separate lines of work on this versatile pathway now indicate that despite its central role as an avenue of cellular quality control, ERAD is also harnessed for feedback regulation of sterol synthesis, and most likely numerous other cellular processes [28].
  • Cytosolic accumulation of prion protein seems to be neurotoxic and might occur when proteasome function is compromised and quality control is overwhelmed [29].
  • We report that a key pathway of ER quality control consists of a two-lectin receptor system consisting of Yos9p and Htm1/Mnl1p that recognizes N-linked glycan signals embedded in substrates [30].
  • One quality control factor is HtrA, one of a new class of oligomeric serine proteases [31].
  • Two central issues in polyglutamine-induced neurodegeneration are the influence of the normal function of the disease protein and modulation by protein quality control pathways [32].

Gene context of Quality Control

  • We propose that at this confined site the perinuclear Mlp1 implements a quality control step prior to export, physically retaining faulty pre-mRNAs [33].
  • Calnexin is a ubiquitous ER chaperone that plays a major role in quality control by retaining incompletely folded or misfolded proteins [34].
  • The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments [35].
  • Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control [36].
  • We conclude that the chaperone PDI is part of the quality control machinery in the ER that recognizes terminally misfolded secretory proteins and targets them to the export channel in the ER membrane [37].

Analytical, diagnostic and therapeutic context of Quality Control


  1. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Meacham, G.C., Patterson, C., Zhang, W., Younger, J.M., Cyr, D.M. Nat. Cell Biol. (2001) [Pubmed]
  2. PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide. Spiers, A., Lamb, H.K., Cocklin, S., Wheeler, K.A., Budworth, J., Dodds, A.L., Pallen, M.J., Maskell, D.J., Charles, I.G., Hawkins, A.R. J. Biol. Chem. (2002) [Pubmed]
  3. The FtsH protease slr0228 is important for quality control of photosystem II in the thylakoid membrane of Synechocystis sp. PCC 6803. Komenda, J., Barker, M., Kuviková, S., de Vries, R., Mullineaux, C.W., Tichy, M., Nixon, P.J. J. Biol. Chem. (2006) [Pubmed]
  4. Differential protein synthesis and expression levels in normal and neoplastic human prostate cells and their regulation by type I and II interferons. Nagano, K., Masters, J.R., Akpan, A., Yang, A., Corless, S., Wood, C., Hastie, C., Zvelebil, M., Cramer, R., Naaby-Hansen, S. Oncogene (2004) [Pubmed]
  5. Escherichia coli ATCC 35218 as a quality control isolate for susceptibility testing of Haemophilus influenzae with haemophilus test medium. Butler, D.L., Jakielaszek, C.J., Miller, L.A., Poupard, J.A. Antimicrob. Agents Chemother. (1999) [Pubmed]
  6. Using the ID3 algorithm to find discrepant diagnoses from laboratory databases of thyroid patients. Forsström, J., Nuutila, P., Irjala, K. Medical decision making : an international journal of the Society for Medical Decision Making. (1991) [Pubmed]
  7. Alpha fetoprotein screening and diagnosis of fetal open neural tube defects: the need for quality control. Wald, N.J., Cuckle, H.S., Catz, C., Dayton, D., Reimer, C.B. Am. J. Obstet. Gynecol. (1981) [Pubmed]
  8. Roles of N-linked glycans in the endoplasmic reticulum. Helenius, A., Aebi, M. Annu. Rev. Biochem. (2004) [Pubmed]
  9. Degradation-mediated protein quality control in the nucleus. Gardner, R.G., Nelson, Z.W., Gottschling, D.E. Cell (2005) [Pubmed]
  10. Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways. McClellan, A.J., Scott, M.D., Frydman, J. Cell (2005) [Pubmed]
  11. Ro's role in RNA reconnaissance. Macrae, I.J., Doudna, J.A. Cell (2005) [Pubmed]
  12. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Nolden, M., Ehses, S., Koppen, M., Bernacchia, A., Rugarli, E.I., Langer, T. Cell (2005) [Pubmed]
  13. In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp. Pendland, S.L., Piscitelli, S.C., Schreckenberger, P.C., Danziger, L.H. Antimicrob. Agents Chemother. (1994) [Pubmed]
  14. In vitro antimicrobial activity of tigemonam, a new orally administered monobactam. Fuchs, P.C., Jones, R.N., Barry, A.L. Antimicrob. Agents Chemother. (1988) [Pubmed]
  15. Preparation and stability of freeze-dried Neisseria gonorrhoeae cultures used for external quality control. Mehaffey, M.A., Cook, E.C., Griffin, C.W. J. Clin. Microbiol. (1984) [Pubmed]
  16. Proposed interpretive criteria and quality control parameters for testing in vitro susceptibility of Neisseria gonorrhoeae to ciprofloxacin. Fuchs, P.C., Barry, A.L., Baker, C., Murray, P.R., Washington, J.A. J. Clin. Microbiol. (1991) [Pubmed]
  17. Development of revised quality control limits for disk diffusion susceptibility tests of selected cephem antibiotics with Haemophilus influenzae and description of a new control strain. Jorgensen, J.H., Barry, A.L., Doern, G.V., Ferraro, M.J., Murray, P.R. J. Clin. Microbiol. (1992) [Pubmed]
  18. The Structure of calnexin, an ER chaperone involved in quality control of protein folding. Schrag, J.D., Bergeron, J.J., Li, Y., Borisova, S., Hahn, M., Thomas, D.Y., Cygler, M. Mol. Cell (2001) [Pubmed]
  19. Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Flynn, J.M., Neher, S.B., Kim, Y.I., Sauer, R.T., Baker, T.A. Mol. Cell (2003) [Pubmed]
  20. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Xue, D., Shi, H., Smith, J.D., Chen, X., Noe, D.A., Cedervall, T., Yang, D.D., Eynon, E., Brash, D.E., Kashgarian, M., Flavell, R.A., Wolin, S.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  21. Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Libri, D., Dower, K., Boulay, J., Thomsen, R., Rosbash, M., Jensen, T.H. Mol. Cell. Biol. (2002) [Pubmed]
  22. Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase. Failer, B.U., Braun, N., Zimmermann, H. J. Biol. Chem. (2002) [Pubmed]
  23. Proteolysis and sterol regulation. Hampton, R.Y. Annu. Rev. Cell Dev. Biol. (2002) [Pubmed]
  24. A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Reggiori, F., Pelham, H.R. Nat. Cell Biol. (2002) [Pubmed]
  25. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. Sharma, M., Pampinella, F., Nemes, C., Benharouga, M., So, J., Du, K., Bache, K.G., Papsin, B., Zerangue, N., Stenmark, H., Lukacs, G.L. J. Cell Biol. (2004) [Pubmed]
  26. Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. Suzuki, T., Yano, K., Sugimoto, S., Kitajima, K., Lennarz, W.J., Inoue, S., Inoue, Y., Emori, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli. Hayes, C.S., Bose, B., Sauer, R.T. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  28. ER-associated degradation in protein quality control and cellular regulation. Hampton, R.Y. Curr. Opin. Cell Biol. (2002) [Pubmed]
  29. Prion proteins meet protein quality control. Dimcheff, D.E., Portis, J.L., Caughey, B. Trends Cell Biol. (2003) [Pubmed]
  30. Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Kim, W., Spear, E.D., Ng, D.T. Mol. Cell (2005) [Pubmed]
  31. The HtrA family of proteases: implications for protein composition and cell fate. Clausen, T., Southan, C., Ehrmann, M. Mol. Cell (2002) [Pubmed]
  32. Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Warrick, J.M., Morabito, L.M., Bilen, J., Gordesky-Gold, B., Faust, L.Z., Paulson, H.L., Bonini, N.M. Mol. Cell (2005) [Pubmed]
  33. Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Galy, V., Gadal, O., Fromont-Racine, M., Romano, A., Jacquier, A., Nehrbass, U. Cell (2004) [Pubmed]
  34. The putative chaperone calmegin is required for sperm fertility. Ikawa, M., Wada, I., Kominami, K., Watanabe, D., Toshimori, K., Nishimune, Y., Okabe, M. Nature (1997) [Pubmed]
  35. The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments. Park, B., Lee, S., Kim, E., Chang, S., Jin, M., Ahn, K. Immunity (2001) [Pubmed]
  36. Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Molinari, M., Eriksson, K.K., Calanca, V., Galli, C., Cresswell, P., Michalak, M., Helenius, A. Mol. Cell (2004) [Pubmed]
  37. Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase. Gillece, P., Luz, J.M., Lennarz, W.J., de La Cruz, F.J., Römisch, K. J. Cell Biol. (1999) [Pubmed]
  38. Alternate site testing for HbA1c using the Primus CLC330 GHb analyzer. Phillipov, G., Charles, P., Beng, C., Phillips, P.J. Diabetes Care (1997) [Pubmed]
  39. Natural rubber latex skin testing reagents: safety and diagnostic accuracy of nonammoniated latex, ammoniated latex, and latex rubber glove extracts. Hamilton, R.G., Adkinson, N.F. J. Allergy Clin. Immunol. (1996) [Pubmed]
  40. The clinical evaluation of HER-2 status: which test to use? Bartlett, J., Mallon, E., Cooke, T. J. Pathol. (2003) [Pubmed]
  41. Use of a quality-control plasma sample to decrease interassay variation in radioimmunoassays of apolipoprotein A-I. Au, Y.P., Hallaway, B.J., Kottke, B.A. Clin. Chem. (1986) [Pubmed]
  42. Preliminary experience in external quality control of RT-PCR PML-RAR alpha detection in promyelocytic leukemia. Bolufer, P., Barragán, E., Sánz, M.A., Martín, G., Bornstein, R., Colomer, D., Delgado, M.D., González, M., Marugan, I., Román, J., Gómez, M.T., Anguita, E., Diverio, D., Chomienne, C., Briz, M. Leukemia (1998) [Pubmed]
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