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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Piper, K.E. et al.

Ketolide treatment of Haemophilus influenzae experimental pneumonia.

The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 micrograms/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.[1]

References

Ketolide treatment of Haemophilus influenzae experimental pneumonia. Piper, K.E., Rouse, M.S., Steckelberg, J.M., Wilson, W.R., Patel, R. Antimicrob. Agents Chemother. (1999) [Pubmed]

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