Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Dörner, A. et al.

Dörner, Olesch, Giessen, Pauschinger, Schultheiss,

Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat.

Two different isoforms of the adenine nucleotide translocase (ANT1 and ANT2) have been identified in the rat. In order to obtain enhanced knowledge of the ANT isoform expression, we analyzed the transcription pattern of both isoforms and their mRNA levels in various tissues of the rat using the PCR technique. A predominant ANT1 mRNA percentage was recorded in the skeletal muscle, heart and brain, ranging from 81 to 58%. In contrast to these tissues, the percentages of ANT2 were dominant with a range from 59 to 75% in the kidney, lung, spleen and liver. The level of total ANT mRNA varied markedly in the various organs. Tissues with a dominant ANT1 percentage simultaneously showed a high level of total ANT transcription (24-41 attomol/ng total RNA). In comparison to the latter, tissues with a prevalent ANT2 transcription were shown to have an even lower ANT transcription level (2-5 attomol/ng total RNA). The predominance of the ANT1 expression appeared to be restricted to tissues with an inability to regenerate by means of mitotic division, whereas a prevalent ANT2 transcription is found in cell types able to proliferate. The level of total ANT transcription but not the individual ANT isoform expression depends to a great extent on the energy requirements of the tissue.[1]

References

Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat. Dörner, A., Olesch, M., Giessen, S., Pauschinger, M., Schultheiss, H.P. Biochim. Biophys. Acta (1999) [Pubmed]

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