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Gene Review

Slc25a4  -  solute carrier family 25 (mitochondrial...

Rattus norvegicus

Synonyms: ADP,ATP carrier protein 1, ADP/ATP translocase 1, ANT 1, Adenine nucleotide translocator 1, Ant1, ...
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Disease relevance of Slc25a4


High impact information on Slc25a4


Biological context of Slc25a4


Anatomical context of Slc25a4


Associations of Slc25a4 with chemical compounds


Regulatory relationships of Slc25a4


Other interactions of Slc25a4


Analytical, diagnostic and therapeutic context of Slc25a4


  1. Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria. Ciapaite, J., Van Eikenhorst, G., Bakker, S.J., Diamant, M., Heine, R.J., Wagner, M.J., Westerhoff, H.V., Krab, K. Diabetes (2005) [Pubmed]
  2. Preconditioning preserves mitochondrial function and glycolytic flux during an early period of reperfusion in perfused rat hearts. Yabe, K., Nasa, Y., Sato, M., Iijima, R., Takeo, S. Cardiovasc. Res. (1997) [Pubmed]
  3. Effect of thyroidectomy on the kinetics of ADP-ATP translocation in liver mitochondria. Mak, I.T., Shrago, E., Elson, C.E. Arch. Biochem. Biophys. (1983) [Pubmed]
  4. Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells. Fischer, R., Schmitt, M., Bode, J.G., Häussinger, D. Gastroenterology (2001) [Pubmed]
  5. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Kinnally, K.W., Zorov, D.B., Antonenko, Y.N., Snyder, S.H., McEnery, M.W., Tedeschi, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. Colell, A., García-Ruiz, C., Lluis, J.M., Coll, O., Mari, M., Fernández-Checa, J.C. J. Biol. Chem. (2003) [Pubmed]
  7. Differential regulation of adenine nucleotide translocators by hypertonicity in the brain. Yamashita, T., Yamauchi, A., Miyai, A., Taniguchi, M., Yoshimine, T., Tohyama, M. J. Neurochem. (1999) [Pubmed]
  8. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Costantini, P., Belzacq, A.S., Vieira, H.L., Larochette, N., de Pablo, M.A., Zamzami, N., Susin, S.A., Brenner, C., Kroemer, G. Oncogene (2000) [Pubmed]
  9. Inhibition of adenine nucleotide translocator by lipid peroxidation products. Chen, J.J., Bertrand, H., Yu, B.P. Free Radic. Biol. Med. (1995) [Pubmed]
  10. Expression of mitochondrial uncoupling protein 3 and adenine nucleotide translocase 1 genes in developing rat heart: putative involvement in control of mitochondrial membrane potential. Skárka, L., Bardová, K., Brauner, P., Flachs, P., Jarkovská, D., Kopecký, J., Ostádal, B. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  11. Isolation and characterization of cDNA clones and a genomic clone encoding rat mitochondrial adenine nucleotide translocator. Shinohara, Y., Kamida, M., Yamazaki, N., Terada, H. Biochim. Biophys. Acta (1993) [Pubmed]
  12. Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat. Dörner, A., Olesch, M., Giessen, S., Pauschinger, M., Schultheiss, H.P. Biochim. Biophys. Acta (1999) [Pubmed]
  13. Identification of IL-1beta-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA. Chen, M.C., Schuit, F., Eizirik, D.L. Diabetologia (1999) [Pubmed]
  14. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. Cao, G., Minami, M., Pei, W., Yan, C., Chen, D., O'Horo, C., Graham, S.H., Chen, J. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  15. Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D. Vyssokikh, M.Y., Katz, A., Rueck, A., Wuensch, C., Dörner, A., Zorov, D.B., Brdiczka, D. Biochem. J. (2001) [Pubmed]
  16. Transcript levels for nuclear-encoded mammalian mitochondrial respiratory-chain components are regulated by thyroid hormone in an uncoordinated fashion. Luciakova, K., Nelson, B.D. Eur. J. Biochem. (1992) [Pubmed]
  17. Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. Vesce, S., Jekabsons, M.B., Johnson-Cadwell, L.I., Nicholls, D.G. J. Biol. Chem. (2005) [Pubmed]
  18. Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin. Welsh, N., Pääbo, S., Welsh, M. Diabetologia (1991) [Pubmed]
  19. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Brenner, C., Cadiou, H., Vieira, H.L., Zamzami, N., Marzo, I., Xie, Z., Leber, B., Andrews, D., Duclohier, H., Reed, J.C., Kroemer, G. Oncogene (2000) [Pubmed]
  20. Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis. Teodoro, J., Rolo, A.P., Oliveira, P.J., Palmeira, C.M. FEBS Lett. (2006) [Pubmed]
  21. Factors determining the relative contribution of the adenine-nucleotide translocator and the ADP-regenerating system to the control of oxidative phosphorylation in isolated rat-liver mitochondria. Wanders, R.J., Groen, A.K., Van Roermund, C.W., Tager, J.M. Eur. J. Biochem. (1984) [Pubmed]
  22. Adenylate kinase is a source of ATP for tumor mitochondrial hexokinase. Nelson, B.D., Kabir, F. Biochim. Biophys. Acta (1985) [Pubmed]
  23. Control of mitochondrial respiration. Tager, J.M., Wanders, R.J., Groen, A.K., Kunz, W., Bohnensack, R., Küster, U., Letko, G., Böhme, G., Duszynski, J., Wojtczak, L. FEBS Lett. (1983) [Pubmed]
  24. Estrogen stimulates expression of adenine nucleotide translocator ANT1 messenger RNA in female rat hearts. Too, C.K., Giles, A., Wilkinson, M. Mol. Cell. Endocrinol. (1999) [Pubmed]
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