High impact information on Slc25a5

• It was assumed that ANT-1 and ANT-2 co-exist in every single mitochondrion and might be differently distributed within the membrane structures that constitute the peripheral inner membrane or the crista membrane [1].
• Microscopic examination showed that ANT2 signals were present in the neurons, as well as glial cells [2].
• From these results we conclude that the T3-mediated transcriptional induction leading to increased activity of ANT2 and mGPDH contributes considerably to the increase in mitochondrial oxygen consumption in rat tissues [3].
• The key role of ANT2 in the control of hyperthyroid metabolism is evident because the expression of the mersalyl-sensitive phosphate carrier and the mitochondrial creatine kinase mRNA, which are functionally linked to ANT, did not respond to T3 [3].
• The significance of ANT2 induction is also discussed with respect to the rapid respiratory response induced by thyroid hormone [4].

Anatomical context of Slc25a5

• These two clones corresponded to the heart-skeletal muscle type (ANT1) and fibroblast type (ANT2), respectively [5].

Associations of Slc25a5 with chemical compounds

• Using ANT-isotype-specific antibodies and sequence analysis of the N-terminal end, it was discovered that the peripheral inner membrane contained ANT-1 and ANT-2, whereas the cristal membrane contained exclusively ANT-2 [1].
• In addition, the mRNA for the growth-activated adenine-nucleotide translocator, ANT2, was increased 13-fold and that for the ATPase N,N'-dicyclohexylcarbodiimide-binding protein increased 4-5-fold [4].

Other interactions of Slc25a5

• A single low dose of triiodothyronine induces rapid increases in cytochrome-c1 and ANT2 mRNA species which parallel changes in the activity of the hormone-responsive malic enzyme, but are earlier than other mitochondrial biogenetic events [4].

Analytical, diagnostic and therapeutic context of Slc25a5

• To see the localization and regulation of ANT2 mRNA in the brain, we performed in situ hybridization of rat brain after intraperitoneal injection of a high concentration of NaCl [2].

References