The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neurotrophin-3 increases neurite outgrowth and apoptosis in explants of the chicken neural plate.

This study examined the effect of neurotrophin-3 (NT-3) on neurite outgrowth and apoptosis of chicken neural plate explants prior to neural tube formation. In situ hybridization revealed that mRNA for the full-length (catalytic) NT-3 receptor, TrkC, was present in, and limited to, the neural plate (including the neural folds) coincident with its formation. Neural plate explants were maintained in vitro on a collagen gel under serum-free conditions in the presence or absence of exogenous NT-3 and/or an antibody to NT-3. In the absence of exogenous NT-3, explants exhibited neurite outgrowth after several days in vitro; apoptotic cells were also seen after 2 days in vitro. This does not appear to be due to endogenous NT-3, since the total number of neurites or apoptotic cells was unchanged if explants were exposed to an NT-3 antibody for the entire culture period. In the presence of exogenous NT-3, neural plate explants exhibited a dose-dependent statistically significant increase in the total number of neurites as compared to explants maintained under control conditions, as well as a statistically significant increase in apoptosis. These NT-3 effects were blocked by an NT-3 antibody. In contrast, NT-3 had no effect on the length of neurites. These findings suggest that NT-3 may play a role during early neural development in vivo.[1]


WikiGenes - Universities