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Gene Review:

NTRK3 - neurotrophic tyrosine kinase, receptor,...

Gallus gallus

Escandón, E. et al., Li, R. et al., Lefcort, F. et al., Garner, A.S. et al., Lin, M.I. et al.

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High impact information on NTRK3

Inhibition of the NT-3 receptor TrkC, early in chick embryogenesis, results in severe reductions in multiple neuronal subpopulations in the dorsal root ganglia [1].
In chicken embryonic retina and optic tectum we detected full-length TrkB and TrkC; however, the optic tectum also expressed large amounts of the truncated form of TrkB [2].
Full-length TrkB and TrkC receptors were found in chicken and rat embryonic ventral spinal cord, as well as on purified motoneurons [2].
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo [3].

Other interactions of NTRK3

In situ hybridization revealed that mRNA for the full-length (catalytic) NT-3 receptor, TrkC, was present in, and limited to, the neural plate (including the neural folds) coincident with its formation [4].
During chicken embryonic and early postnatal brain development, expression of full-length TrkB and TrkC proteins preceded the onset of the truncated forms of these receptors [2].

Analytical, diagnostic and therapeutic context of NTRK3

TrkC receptor isoforms have been identified by cDNA cloning and RT-PCR analysis of embryonic chick brain RNA [5].

References

Inhibition of the NT-3 receptor TrkC, early in chick embryogenesis, results in severe reductions in multiple neuronal subpopulations in the dorsal root ganglia. Lefcort, F., Clary, D.O., Rusoff, A.C., Reichardt, L.F. J. Neurosci. (1996) [Pubmed]
Regulation of neurotrophin receptor expression during embryonic and postnatal development. Escandón, E., Soppet, D., Rosenthal, A., Mendoza-Ramírez, J.L., Szönyi, E., Burton, L.E., Henderson, C.E., Parada, L.F., Nikolics, K. J. Neurosci. (1994) [Pubmed]
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. Lin, M.I., Das, I., Schwartz, G.M., Tsoulfas, P., Mikawa, T., Hempstead, B.L. Dev. Biol. (2000) [Pubmed]
Neurotrophin-3 increases neurite outgrowth and apoptosis in explants of the chicken neural plate. Li, R., Bernd, P. Dev. Neurosci. (1999) [Pubmed]
Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival. Garner, A.S., Large, T.H. Neuron (1994) [Pubmed]

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