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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immune cell signaling defects in lupus: activation, anergy and death.

Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.[1]


  1. Immune cell signaling defects in lupus: activation, anergy and death. Tsokos, G.C., Liossis, S.N. Immunol. Today (1999) [Pubmed]
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