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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.[1]


  1. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Leevers, S.J., Vanhaesebroeck, B., Waterfield, M.D. Curr. Opin. Cell Biol. (1999) [Pubmed]
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