Gene Review:
PTEN - phosphatase and tensin homolog
Homo sapiens
Synonyms:
10q23del, BZS, CWS1, DEC, GLM2, ...
Stoffel,
Athanassios Dellas,
Gernot Jundt,
Gideon Sartorius,
Mischa Schneider,
Holger Moch,
Levine,
Zhang,
Traverso,
Goberdhan,
Walsh,
Vogelstein,
Bulloj,
Liao,
Howe,
O-Charoenrat,
Singh,
Dixon,
Sayed,
Zhang,
Woods,
Zhou,
Reddy,
Findley,
Velculescu,
Jiang,
Taylor,
Chou,
Ngai,
Anderson,
Dao,
Liu,
Petersen,
Maehama,
Rao,
Zhang,
Xu,
Mitros,
Gu,
Tong,
Bair,
- PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001)
- Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Kurose, K., Gilley, K., Matsumoto, S., Watson, P.H., Zhou, X.P., Eng, C. Nat. Genet. (2002)
- The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Hamada, K., Sasaki, T., Koni, P.A., Natsui, M., Kishimoto, H., Sasaki, J., Yajima, N., Horie, Y., Hasegawa, G., Naito, M., Miyazaki, J., Suda, T., Itoh, H., Nakao, K., Mak, T.W., Nakano, T., Suzuki, A. Genes Dev. (2005)
- Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Manning, B.D., Logsdon, M.N., Lipovsky, A.I., Abbott, D., Kwiatkowski, D.J., Cantley, L.C. Genes Dev. (2005)
- PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Kim, S., Domon-Dell, C., Wang, Q., Chung, D.H., Di Cristofano, A., Pandolfi, P.P., Freund, J.N., Evers, B.M. Gastroenterology (2002)
- EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. Selvendiran, K., Tong, L., Vishwanath, S., Bratasz, A., Trigg, N.J., Kutala, V.K., Hideg, K., Kuppusamy, P. J. Biol. Chem. (2007)
- Phosphatase PTEN in neuronal injury and brain disorders. Chang, N., El-Hayek, Y.H., Gomez, E., Wan, Q. Trends Neurosci. (2007)
- PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. Silva, A., Yunes, J.A., Cardoso, B.A., Martins, L.R., Jotta, P.Y., Abecasis, M., Nowill, A.E., Leslie, N.R., Cardoso, A.A., Barata, J.T. J. Clin. Invest. (2008)
- Combined PTEN and p27kip1 protein expression patterns are associated with obesity and prognosis in endometrial carcinomas. Dellas, A., Jundt, G., Sartorius, G., Schneider, M., Moch, H. Clin. Cancer Res. (2009)
- The role of PTEN, a phosphatase gene, in inherited and sporadic nonmedullary thyroid tumors. Eng, C. Recent Prog. Horm. Res. (1999)
- Expression of the PTEN tumour suppressor protein during human development. Gimm, O., Attié-Bitach, T., Lees, J.A., Vekemans, M., Eng, C. Hum. Mol. Genet. (2000)
- Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. Griffin, R.J., Moloney, A., Kelliher, M., Johnston, J.A., Ravid, R., Dockery, P., O'Connor, R., O'Neill, C. J. Neurochem. (2005)
- Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Zhang, X., Zhang, Y.W., Liu, S., Bulloj, A., Tong, G.G., Zhang, Z., Liao, F.F., Xu, H. Molecular neurodegeneration [electronic resource]. (2006)
- Pten and the Brain: Sizing up Social Interaction. Greer, J.M., Wynshaw-Boris, A. Neuron (2006)
- Phosphoinositides Specify Polarity during Epithelial Organ Development. Comer, F.I., Parent, C.A. Cell (2007)
- Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. Gu, J., Tamura, M., Yamada, K.M. J. Cell Biol. (1998)
- PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Radu, A., Neubauer, V., Akagi, T., Hanafusa, H., Georgescu, M.M. Mol. Cell. Biol. (2003)
- PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Weng, L.P., Brown, J.L., Eng, C. Hum. Mol. Genet. (2001)
- Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B. Carson, J.P., Kulik, G., Weber, M.J. Cancer Res. (1999)
- Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Van de Sande, T., De Schrijver, E., Heyns, W., Verhoeven, G., Swinnen, J.V. Cancer Res. (2002)
- Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G., Vogelstein, B. Nat. Genet. (2001)
- Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Sasaki, T., Irie-Sasaki, J., Horie, Y., Bachmaier, K., Fata, J.E., Li, M., Suzuki, A., Bouchard, D., Ho, A., Redston, M., Gallinger, S., Khokha, R., Mak, T.W., Hawkins, P.T., Stephens, L., Scherer, S.W., Tsao, M., Penninger, J.M. Nature (2000)
- Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J., Cantley, L.C. Mol. Cell (2002)
- Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. Xu, X., Kobayashi, S., Qiao, W., Li, C., Xiao, C., Radaeva, S., Stiles, B., Wang, R.H., Ohara, N., Yoshino, T., LeRoith, D., Torbenson, M.S., Gores, G.J., Wu, H., Gao, B., Deng, C.X. J. Clin. Invest. (2006)
- Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Li, X., Leu, S., Cheong, A., Zhang, H., Baibakov, B., Shih, C., Birnbaum, M.J., Donowitz, M. Gastroenterology (2004)
- Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. Persad, S., Troussard, A.A., McPhee, T.R., Mulholland, D.J., Dedhar, S. J. Cell Biol. (2001)
- The myotubularin family: from genetic disease to phosphoinositide metabolism. Laporte, J., Blondeau, F., Buj-Bello, A., Mandel, J.L. Trends Genet. (2001)
- PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Li, D.M., Sun, H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Protean PTEN: form and function. Waite, K.A., Eng, C. Am. J. Hum. Genet. (2002)
- PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. Zhou, M., Gu, L., Findley, H.W., Jiang, R., Woods, W.G. Cancer Res. (2003)
- Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Lu, C.H., Wyszomierski, S.L., Tseng, L.M., Sun, M.H., Lan, K.H., Neal, C.L., Mills, G.B., Hortobagyi, G.N., Esteva, F.J., Yu, D. Clin. Cancer Res. (2007)
- Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. Odriozola, L., Singh, G., Hoang, T., Chan, A.M. J. Biol. Chem. (2007)
- PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Yang, L., Clarke, M.J., Carlson, B.L., Mladek, A.C., Schroeder, M.A., Decker, P., Wu, W., Kitange, G.J., Grogan, P.T., Goble, J.M., Uhm, J., Galanis, E., Giannini, C., Lane, H.A., James, C.D., Sarkaria, J.N. Clin. Cancer Res. (2008)
- Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA. Kim, J.S., Lee, C., Bonifant, C.L., Ressom, H., Waldman, T. Mol. Cell. Biol. (2007)
- PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. Tamura, M., Gu, J., Danen, E.H., Takino, T., Miyamoto, S., Yamada, K.M. J. Biol. Chem. (1999)
- TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. Vogelmann, R., Nguyen-Tat, M.D., Giehl, K., Adler, G., Wedlich, D., Menke, A. J. Cell. Sci. (2005)
- Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. Vazquez, F., Grossman, S.R., Takahashi, Y., Rokas, M.V., Nakamura, N., Sellers, W.R. J. Biol. Chem. (2001)
- Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Minaguchi, T., Waite, K.A., Eng, C. Cancer Res. (2006)
- LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Mehenni, H., Lin-Marq, N., Buchet-Poyau, K., Reymond, A., Collart, M.A., Picard, D., Antonarakis, S.E. Hum. Mol. Genet. (2005)
- Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. Saito, Y., Gopalan, B., Mhashilkar, A.M., Roth, J.A., Chada, S., Zumstein, L., Ramesh, R. Cancer Gene Ther. (2003)
- PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells. Kang-Park, S., Lee, Y.I., Lee, Y.I. FEBS Lett. (2003)
- BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Waite, K.A., Eng, C. Hum. Mol. Genet. (2003)
- Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Gomez-Manzano, C., Fueyo, J., Jiang, H., Glass, T.L., Lee, H.Y., Hu, M., Liu, J.L., Jasti, S.L., Liu, T.J., Conrad, C.A., Yung, W.K. Ann. Neurol. (2003)
- Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. Li, P., Nicosia, S.V., Bai, W. J. Biol. Chem. (2001)
- PTEN regulates phospholipase D and phospholipase C. Alvarez-Breckenridge, C.A., Waite, K.A., Eng, C. Hum. Mol. Genet. (2007)
- Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Chudnovsky, Y., Adams, A.E., Robbins, P.B., Lin, Q., Khavari, P.A. Nat. Genet. (2005)
- p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Singh, B., Reddy, P.G., Goberdhan, A., Walsh, C., Dao, S., Ngai, I., Chou, T.C., O-Charoenrat, P., Levine, A.J., Rao, P.H., Stoffel, A. Genes Dev. (2002)
- PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Wishart, M.J., Dixon, J.E. Trends Cell Biol. (2002)
- The role of PTEN in prostate cancer cell tropism to the bone micro-environment. Wu, Z., McRoberts, K.S., Theodorescu, D. Carcinogenesis (2007)
- Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. Wang, Q., Zhou, Y., Wang, X., Chung, D.H., Evers, B.M. Cancer Res. (2007)
- mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Majumder, P.K., Febbo, P.G., Bikoff, R., Berger, R., Xue, Q., McMahon, L.M., Manola, J., Brugarolas, J., McDonnell, T.J., Golub, T.R., Loda, M., Lane, H.A., Sellers, W.R. Nat. Med. (2004)
- PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Zhang, C., Comai, L., Johnson, D.L. Mol. Cell. Biol. (2005)
- Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T., Nakamura, Y. Cancer Res. (2001)