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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Establishment and characterization of a mouse strain ( TLL) that spontaneously develops T-cell lymphomas/leukemia.

In this study, a mouse strain ( TLL) that spontaneously develops T-cell lymphomas/leukemia with an early onset and high incidence was established and characterized. All tumors analyzed were found to express the alpha,beta T-cell receptor, and the majority of them had a mature, CD3+CD4+CD8- immunophenotype. In a few cases, tumors with a more immature CD3+CD4+CD8+ phenotype were isolated. Expanded phenotyping using a broad panel of lymphocyte differentiation markers confirmed the mature T-cell phenotype of the tumors. Histologic and cell cycle analysis of the tumors revealed an aggressive lymphoblastic malignancy with a very high proliferation rate and widespread engagement of bone marrow and lymphoid as well as nonlymphoid organs. Thus, the TLL mouse strain represents a unique model for the analysis of the oncogenesis and progression of mature T-cell tumors and for the development of therapeutic measures to combat such tumors.[1]

References

  1. Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia. Eriksson, B., Johansson, A.S., Roos, G., Levan, G., Holmberg, D. Exp. Hematol. (1999) [Pubmed]
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