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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida.

Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 microgram/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 micrograms/ml. Oleanolic acid, alpha-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 micrograms/ml, respectively.[1]

References

  1. Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. Jeong, T.S., Hwang, E.I., Lee, H.B., Lee, E.S., Kim, Y.K., Min, B.S., Bae, K.H., Bok, S.H., Kim, S.U. Planta Med. (1999) [Pubmed]
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