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Chemical Compound Review

AC1L9PSE     (1S,2R,4aS,6aR,6aS,6bR,8aR,9S, 10S,12aS...

Synonyms: 125343-13-7
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Disease relevance of Triterpenoid


High impact information on Triterpenoid


Chemical compound and disease context of Triterpenoid


Biological context of Triterpenoid


Anatomical context of Triterpenoid


Associations of Triterpenoid with other chemical compounds


Gene context of Triterpenoid


Analytical, diagnostic and therapeutic context of Triterpenoid


  1. Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. Curreli, F., Friedman-Kien, A.E., Flore, O. J. Clin. Invest. (2005) [Pubmed]
  2. A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis. Minns, L.A., Buzoni-Gatel, D., Ely, K.H., Rachinel, N., Luangsay, S., Kasper, L.H. Gastroenterology (2004) [Pubmed]
  3. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Konopleva, M., Tsao, T., Ruvolo, P., Stiouf, I., Estrov, Z., Leysath, C.E., Zhao, S., Harris, D., Chang, S., Jackson, C.E., Munsell, M., Suh, N., Gribble, G., Honda, T., May, W.S., Sporn, M.B., Andreeff, M. Blood (2002) [Pubmed]
  4. Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells. Lapillonne, H., Konopleva, M., Tsao, T., Gold, D., McQueen, T., Sutherland, R.L., Madden, T., Andreeff, M. Cancer Res. (2003) [Pubmed]
  5. Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast. Gutterman, J.U., Lai, H.T., Yang, P., Haridas, V., Gaikwad, A., Marcus, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Haridas, V., Higuchi, M., Jayatilake, G.S., Bailey, D., Mujoo, K., Blake, M.E., Arntzen, C.J., Gutterman, J.U. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Haralampidis, K., Bryan, G., Qi, X., Papadopoulou, K., Bakht, S., Melton, R., Osbourn, A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Hanausek, M., Ganesh, P., Walaszek, Z., Arntzen, C.J., Slaga, T.J., Gutterman, J.U. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Liby, K., Royce, D.B., Williams, C.R., Risingsong, R., Yore, M.M., Honda, T., Gribble, G.W., Dmitrovsky, E., Sporn, T.A., Sporn, M.B. Cancer Res. (2007) [Pubmed]
  10. The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. Ito, Y., Pandey, P., Sporn, M.B., Datta, R., Kharbanda, S., Kufe, D. Mol. Pharmacol. (2001) [Pubmed]
  11. Triterpenoid carotenoids and related lipids. Triterpenoid carotenoid aldehydes from Streptococcus faecium UNH 564P. Taylor, R.F., Davies, B.H. Biochem. J. (1976) [Pubmed]
  12. Fusidic acid suppresses nitric oxide toxicity in pancreatic islet cells. Burkart, V., Bellmann, K., Hartmann, B., Heller, B., Imai, Y., Kolb, H. Biochem. Pharmacol. (1994) [Pubmed]
  13. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Danloy, S., Quetin-Leclercq, J., Coucke, P., De Pauw-Gillet, M.C., Elias, R., Balansard, G., Angenot, L., Bassleer, R. Planta Med. (1994) [Pubmed]
  14. Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis. Mujoo, K., Haridas, V., Hoffmann, J.J., Wächter, G.A., Hutter, L.K., Lu, Y., Blake, M.E., Jayatilake, G.S., Bailey, D., Mills, G.B., Gutterman, J.U. Cancer Res. (2001) [Pubmed]
  15. Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives. Rahier, A., Génot, J.C., Schuber, F., Benveniste, P., Narula, A.S. J. Biol. Chem. (1984) [Pubmed]
  16. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. Stadheim, T.A., Suh, N., Ganju, N., Sporn, M.B., Eastman, A. J. Biol. Chem. (2002) [Pubmed]
  17. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Shishodia, S., Sethi, G., Konopleva, M., Andreeff, M., Aggarwal, B.B. Clin. Cancer Res. (2006) [Pubmed]
  18. Effect of sterol replacement in vivo on the fatty acid composition of Tetrahymena. Ferguson, K.A., Davis, F.M., Conner, R.L., Landrey, J.R., Mallory, F.B. J. Biol. Chem. (1975) [Pubmed]
  19. Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Bode, H.B., Zeggel, B., Silakowski, B., Wenzel, S.C., Reichenbach, H., Müller, R. Mol. Microbiol. (2003) [Pubmed]
  20. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis. Couch, R.D., Ganem, N.J., Zhou, M., Popov, V.M., Honda, T., Veenstra, T.D., Sporn, M.B., Anderson, A.C. Mol. Pharmacol. (2006) [Pubmed]
  21. The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. Zhang, C., Ni, X., Konopleva, M., Andreeff, M., Duvic, M. J. Invest. Dermatol. (2004) [Pubmed]
  22. The effect of triterpenoid compounds on uninfected and herpes simplex virus-infected cells in culture. II. DNA and protein synthesis, polypeptide processing and transport. Dargan, D.J., Subak-Sharpe, J.H. J. Gen. Virol. (1986) [Pubmed]
  23. The triterpenoid CDDO induces apoptosis in refractory CLL B cells. Pedersen, I.M., Kitada, S., Schimmer, A., Kim, Y., Zapata, J.M., Charboneau, L., Rassenti, L., Andreeff, M., Bennett, F., Sporn, M.B., Liotta, L.D., Kipps, T.J., Reed, J.C. Blood (2002) [Pubmed]
  24. Triterpenoid CDDO-Me Blocks the NF-{kappa}B Pathway by Direct Inhibition of IKKbeta on Cys-179. Ahmad, R., Raina, D., Meyer, C., Kharbanda, S., Kufe, D. J. Biol. Chem. (2006) [Pubmed]
  25. Steroids, triterpenoids and molecular oxygen. Summons, R.E., Bradley, A.S., Jahnke, L.L., Waldbauer, J.R. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2006) [Pubmed]
  26. Inhibition of NF-kappaB activation through targeting IkappaB kinase by celastrol, a quinone methide triterpenoid. Lee, J.H., Koo, T.H., Yoon, H., Jung, H.S., Jin, H.Z., Lee, K., Hong, Y.S., Lee, J.J. Biochem. Pharmacol. (2006) [Pubmed]
  27. Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. Jeong, T.S., Hwang, E.I., Lee, H.B., Lee, E.S., Kim, Y.K., Min, B.S., Bae, K.H., Bok, S.H., Kim, S.U. Planta Med. (1999) [Pubmed]
  28. The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells. Konopleva, M., Contractor, R., Kurinna, S.M., Chen, W., Andreeff, M., Ruvolo, P.P. Leukemia (2005) [Pubmed]
  29. The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Elliott, S., Hays, E., Mayor, M., Sporn, M., Vincenti, M. Arthritis Res. Ther. (2003) [Pubmed]
  30. Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. Ikeda, T., Kimura, F., Nakata, Y., Sato, K., Ogura, K., Motoyoshi, K., Sporn, M., Kufe, D. Cell Death Differ. (2005) [Pubmed]
  31. Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. Vázquez, N., Greenwell-Wild, T., Marinos, N.J., Swaim, W.D., Nares, S., Ott, D.E., Schubert, U., Henklein, P., Orenstein, J.M., Sporn, M.B., Wahl, S.M. J. Virol. (2005) [Pubmed]
  32. Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes. Ying, Q.L., Rinehart, A.R., Simon, S.R., Cheronis, J.C. Biochem. J. (1991) [Pubmed]
  33. Molecular components of large conductance calcium-activated potassium (BK) channels in mouse pituitary corticotropes. Shipston, M.J., Duncan, R.R., Clark, A.G., Antoni, F.A., Tian, L. Mol. Endocrinol. (1999) [Pubmed]
  34. The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. Liby, K., Voong, N., Williams, C.R., Risingsong, R., Royce, D.B., Honda, T., Gribble, G.W., Sporn, M.B., Letterio, J.J. Clin. Cancer Res. (2006) [Pubmed]
  35. Growth inhibition and apoptosis-induced effect on human cancer cells of toosendanin, a triterpenoid derivative from chinese traditional medicine. Zhang, B., Wang, Z.F., Tang, M.Z., Shi, Y.L. Investigational new drugs. (2005) [Pubmed]
  36. Rapid structural characterization of triterpenoid saponins in crude extract from Symplocos chinensis using liquid chromatography combined with electrospray ionization tandem mass spectrometry. Li, B., Abliz, Z., Tang, M., Fu, G., Yu, S. Journal of chromatography. A. (2006) [Pubmed]
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