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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Successful liver transplantation after induction chemotherapy in children with inoperable, multifocal primary hepatic malignancy.

BACKGROUND: The prognosis for primary epithelial liver tumor in children in whom radical surgery cannot be performed after chemotherapy is poor. Orthotopic liver transplantation has resulted in mortality up to 50%, largely as a result of problems in determining the criteria for transplantation. METHODS: We report results on liver transplantation for primary epithelial liver malignancy in five children (mean age at transplantation: 6.0 years). Only patients with inoperable residual tumor in the liver after four cycles of multidrug chemotherapy, but without extrahepatic infiltration or metastases, were considered eligible for transplantation. RESULTS: Mean follow-up was 4.6 years. Patient and graft survival was 100%, with no signs of residual or de novo malignancy. CONCLUSION: In children with inoperable primary liver malignancy with no extrahepatic tumor growth, orthotopic liver transplantation has an excellent outcome.[1]

References

  1. Successful liver transplantation after induction chemotherapy in children with inoperable, multifocal primary hepatic malignancy. Laine, J., Jalanko, H., Saarinen-Pihkala, U.M., Höckerstedt, K., Leijala, M., Holmberg, C., Heikinheimo, M. Transplantation (1999) [Pubmed]
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