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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Graft Survival

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Disease relevance of Graft Survival


High impact information on Graft Survival


Chemical compound and disease context of Graft Survival


Biological context of Graft Survival


Anatomical context of Graft Survival


Associations of Graft Survival with chemical compounds

  • Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium [26].
  • Treatment of these recipients with as little as 1.5 mg/kg cyclophosphamide for 14 d induces prolonged graft survival [27].
  • Aminoguanidine treatment prolonged graft survival, improved graft contractile function, and significantly reduced the histologic grade of rejection [28].
  • In the absence of cyclosporin A (CsA), there was no difference in graft survival time between CX(3)CR1(-/-) and CX(3)CR1(+/+) recipient mice [29].
  • Two additional in vivo parameters of cellular immunologic reactivity were examined in streptozotocin-induced diabetes: delayed footpad swelling was essentially eliminated; skin graft survival across the H-2 area was significantly prolonged from 10.2 days in the controls to 14.4 days in moderately diabetic A/J mice [30].

Gene context of Graft Survival

  • Decreased graft survival in IL-10 -/- recipients was associated with increases in iNOS and IFN-gamma-driven responses [31].
  • In wild-type and IL-4 -/- recipients immunosuppressed with a 30-d course of anti-CD4 and anti-CD8, graft survival was > 87 d [31].
  • Treatment of the recipients with donor splenocytes and a single dose of anti-CD40L mAb induces long-term graft survival (> 100 days) in all animals [32].
  • A clinical relevance of these findings is suggested by the observation that matching for HLA-B antigens is of greater importance for kidney graft survival than matching for HLA-A [33].
  • Mismatching for HLA-B and DR antigens was also found to correlate with transplant survival in highly sensitized patients and in patients transplanted since 1981, the "cyclosporine era." Recipients who were HLA-DR1 positive were found to have the highest graft survival compared to recipients negative for this antigen [34].

Analytical, diagnostic and therapeutic context of Graft Survival


  1. Preferential effectiveness of cyclosporin in patients receiving kidney transplants after glomerulonephritis. Cats, S., Terasaki, P.I., Perdue, S., Mickey, M.R. Lancet (1985) [Pubmed]
  2. Antibodies against the GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection. Tillmann, H.L., Heringlake, S., Trautwein, C., Meissner, D., Nashan, B., Schlitt, H.J., Kratochvil, J., Hunt, J., Qiu, X., Lou, S.C., Pichlmayr, R., Manns, M.P. Hepatology (1998) [Pubmed]
  3. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. Li, X., Chen, H., Epstein, P.N. J. Biol. Chem. (2004) [Pubmed]
  4. Calcium antagonists and acute renal failure. Russell, J.D., Churchill, D.N. Am. J. Med. (1989) [Pubmed]
  5. Chronic allograft nephropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism. Amuchastegui, S.C., Azzollini, N., Mister, M., Pezzotta, A., Perico, N., Remuzzi, G. J. Am. Soc. Nephrol. (1998) [Pubmed]
  6. High survival rates of kidney transplants from spousal and living unrelated donors. Terasaki, P.I., Cecka, J.M., Gjertson, D.W., Takemoto, S. N. Engl. J. Med. (1995) [Pubmed]
  7. Equitable allocation of HLA-compatible kidneys for local pools and minorities. Takemoto, S., Terasaki, P.I., Gjertson, D.W., Cecka, J.M. N. Engl. J. Med. (1994) [Pubmed]
  8. The benefit of exchanging donor kidneys among transplant centers. Opelz, G. N. Engl. J. Med. (1988) [Pubmed]
  9. Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine. Hall, B.M., Tiller, D.J., Hardie, I., Mahony, J., Mathew, T., Thatcher, G., Miach, P., Thomson, N., Sheil, A.G. N. Engl. J. Med. (1988) [Pubmed]
  10. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Schierle, G.S., Hansson, O., Leist, M., Nicotera, P., Widner, H., Brundin, P. Nat. Med. (1999) [Pubmed]
  11. Hepatitis B and C in the liver transplant recipient. Rosen, H.R., Martin, P. Semin. Liver Dis. (2000) [Pubmed]
  12. Renal transplantation in scleroderma. Chang, Y.J., Spiera, H. Medicine (Baltimore) (1999) [Pubmed]
  13. The effect of kidney size on cadaveric renal allograft outcome. Miles, A.M., Sumrani, N., John, S., Markell, M.S., Distant, D.A., Maursky, V., Hong, J.H., Friedman, E.A., Sommer, B. Transplantation (1996) [Pubmed]
  14. Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation. Murphy, G.J., Taha, R., Windmill, D.C., Metcalfe, M., Nicholson, M.L. The British journal of surgery. (2001) [Pubmed]
  15. Motor function, graft survival and gliosis in rats with 6-OHDA lesions and foetal ventral mesencephalic grafts chronically treated with L-dopa and carbidopa. Blunt, S.B., Jenner, P., Marsden, C.D. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1992) [Pubmed]
  16. Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice. Eliopoulos, N., Stagg, J., Lejeune, L., Pommey, S., Galipeau, J. Blood (2005) [Pubmed]
  17. Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. Wong, C.P., Li, L., Frelinger, J.A., Tisch, R. J. Immunol. (2006) [Pubmed]
  18. Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates. Montgomery, S.P., Hale, D.A., Hirshberg, B., Harlan, D.M., Kirk, A.D. Immunol. Rev. (2001) [Pubmed]
  19. Results of 3-year phase III clinical trials with daclizumab prophylaxis for prevention of acute rejection after renal transplantation. Bumgardner, G.L., Hardie, I., Johnson, R.W., Lin, A., Nashan, B., Pescovitz, M.D., Ramos, E., Vincenti, F. Transplantation (2001) [Pubmed]
  20. Effect of major histocompatibility complex expression on murine intestinal graft survival. Cagiannos, C., Zhong, R., Zang, Z., Jiang, J., Garcia, B.M., Chakrabarti, S., Jevnikar, A.M., Sinclair, N.R., Grant, D.R. Transplantation (1998) [Pubmed]
  21. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. Pinsky, D.J., Naka, Y., Liao, H., Oz, M.C., Wagner, D.D., Mayadas, T.N., Johnson, R.C., Hynes, R.O., Heath, M., Lawson, C.A., Stern, D.M. J. Clin. Invest. (1996) [Pubmed]
  22. Recipient lymphocyte sensitivity to methylprednisolone affects cadaver kidney graft survival. Langhoff, E., Ladefoged, J., Jakobsen, B.K., Platz, P., Ryder, L.P., Svejgaard, A., Thaysen, J.H. Lancet (1986) [Pubmed]
  23. Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha. Nagakawa, Y., Williams, G.M., Zheng, Q., Tsuchida, A., Aoki, T., Montgomery, R.A., Klein, A.S., Sun, Z. Hepatology (2005) [Pubmed]
  24. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. Zhai, Y., Shen, X.D., Gao, F., Coito, A.J., Wasowska, B.A., Salama, A., Schmitt, I., Busuttil, R.W., Sayegh, M.H., Kupiec-Weglinski, J.W. J. Immunol. (2002) [Pubmed]
  25. A role for nonspecific (cyclosporin A) or specific (monoclonal antibodies to ICAM-1, LFA-1, and IL-10) immunomodulation in the prolongation of skin allografts after antigen-specific pretransplant immunization or transfusion. Gorczynski, R.M., Wojcik, D. J. Immunol. (1994) [Pubmed]
  26. Effect of oxygen pressure during culture on survival of mouse thyroid allografts. Talmage, D.W., Dart, G.A. Science (1978) [Pubmed]
  27. Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient. Lechler, R.I., Batchelor, J.R. J. Exp. Med. (1982) [Pubmed]
  28. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. Worrall, N.K., Lazenby, W.D., Misko, T.P., Lin, T.S., Rodi, C.P., Manning, P.T., Tilton, R.G., Williamson, J.R., Ferguson, T.B. J. Exp. Med. (1995) [Pubmed]
  29. Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. Haskell, C.A., Hancock, W.W., Salant, D.J., Gao, W., Csizmadia, V., Peters, W., Faia, K., Fituri, O., Rottman, J.B., Charo, I.F. J. Clin. Invest. (2001) [Pubmed]
  30. Induced and spontaneous diabetes mellitus and suppression of cell-mediated immunologic responses. Granuloma formation, delayed dermal reactivity and allograft rejection. Mahmoud, A.A., Rodman, H.M., Mandel, M.A., Warren, K.S. J. Clin. Invest. (1976) [Pubmed]
  31. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. Räisänen-Sokolowski, A., Mottram, P.L., Glysing-Jensen, T., Satoskar, A., Russell, M.E. J. Clin. Invest. (1997) [Pubmed]
  32. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Hancock, W.W., Sayegh, M.H., Zheng, X.G., Peach, R., Linsley, P.S., Turka, L.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  33. Cytotoxic T lymphocytes against HLA-B antigens are less naive than cytotoxic T lymphocytes against HLA-A antigens. Roelen, D.L., van Bree, S.P., van Beelen, E., Schanz, U., van Rood, J.J., Claas, F.H. Transplantation (1994) [Pubmed]
  34. Evidence that matching for HLA antigens significantly increases transplant survival in 1001 renal transplants performed in the northwest region of England. Dyer, P.A., Johnson, R.W., Martin, S., Bakran, A., Gokal, R., Harris, R., Mallick, N.P., Manos, J., Orr, W.M., Pearson, R.C. Transplantation (1989) [Pubmed]
  35. The association of cyclosporine with the 1-year costs of cadaver-donor kidney transplants. Showstack, J., Katz, P., Amend, W., Salvatierra, O. JAMA (1990) [Pubmed]
  36. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. Mandelbrot, D.A., Oosterwegel, M.A., Shimizu, K., Yamada, A., Freeman, G.J., Mitchell, R.N., Sayegh, M.H., Sharpe, A.H. J. Clin. Invest. (2001) [Pubmed]
  37. Systemic lupus erythematosus after renal transplantation: patient and graft survival and disease activity. The Dutch Working Party on Systemic Lupus Erythematosus. Nossent, H.C., Swaak, T.J., Berden, J.H. Ann. Intern. Med. (1991) [Pubmed]
  38. Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Bottino, R., Fernandez, L.A., Ricordi, C., Lehmann, R., Tsan, M.F., Oliver, R., Inverardi, L. Diabetes (1998) [Pubmed]
  39. Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine. Russell, D.H., Kibler, R., Matrisian, L., Larson, D.F., Poulos, B., Magun, B.E. J. Immunol. (1985) [Pubmed]
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