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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.

In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.[1]

References

  1. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. York, J.D., Odom, A.R., Murphy, R., Ives, E.B., Wente, S.R. Science (1999) [Pubmed]
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