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Cytotoxic 3,4-secoapotirucallanes from Aaglaia argentea bark.

Nine 3,4-secoapotirucallanes, argentinic acids A-I, were isolated from the bark of Aglaia argentea and transformed to their methyl esters 1-9. The structures were determined by spectral and chemical means. Compounds 1-8 showed moderate cytotoxic activity against KB cells (IC50 1.0-3.5 microg/mL).[1]


  1. Cytotoxic 3,4-secoapotirucallanes from Aaglaia argentea bark. Mohamad, K., Martin, M.T., Najdar, H., Gaspard, C., Sévenet, T., Awang, K., Hadi, H., Païs, M. J. Nat. Prod. (1999) [Pubmed]
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