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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An activating immunoreceptor complex formed by NKG2D and DAP10.

Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase ( PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D- DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors.[1]

References

  1. An activating immunoreceptor complex formed by NKG2D and DAP10. Wu, J., Song, Y., Bakker, A.B., Bauer, S., Spies, T., Lanier, L.L., Phillips, J.H. Science (1999) [Pubmed]
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