Gene Review:
KLRK1 - killer cell lectin-like receptor subfamily...
Homo sapiens
Synonyms:
CD314, D12S2489E, KLR, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, ...
Camoriano,
Steinle,
Garg,
Chiara Castelli,
Vankayalapati,
Le Bouteiller,
Adriano Piris,
Boissel,
Beever,
Wu,
Pende,
Poggi,
Girard,
Rotoli,
Hernestål,
Tamouza,
Barnes,
Tassone,
Porgador,
Dulphy,
Spies,
Brun,
Pende,
Miller,
Levreri,
Ferrone,
Gambini,
Chen,
Larson,
Mogren,
Groh,
Rea,
Cosman,
Sutherland,
Spies,
Otsuki,
Rousselot,
Raffaghello,
Licia Rivoltini,
Cosman,
Neri,
Toubert,
Negrini,
Tieng,
Charron,
Safi,
Groh,
Prigione,
Spies,
Antsiferova,
Rabinovich,
Chalupny,
Roe,
Pollio,
Griffith,
Carbone,
Daniela Pende,
Daisuke Nonaka,
Baranov,
Stendahl,
Prevosto,
Giorgio Parmiani,
Klucar,
Mahon,
Marron,
Massaro,
Brawand,
Mincheva-Nilsson,
Zocchi,
Cristina Maccalli,
Pierri,
Venuta,
Cosman,
Catalano,
Saccardi,
Yee,
Gobbi,
Cayuela,
Mesuraca,
Pistoia,
Lewin,
Dombret,
Nagaeva,
Airoldi,
Steinle,
Urbani,
Fulciniti,
- HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Carbone, E., Neri, P., Mesuraca, M., Fulciniti, M.T., Otsuki, T., Pende, D., Groh, V., Spies, T., Pollio, G., Cosman, D., Catalano, L., Tassone, P., Rotoli, B., Venuta, S. Blood (2005)
- Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Pende, D., Rivera, P., Marcenaro, S., Chang, C.C., Biassoni, R., Conte, R., Kubin, M., Cosman, D., Ferrone, S., Moretta, L., Moretta, A. Cancer Res. (2002)
- Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. Lee, J.C., Lee, K.M., Kim, D.W., Heo, D.S. J. Immunol. (2004)
- Expression and function of NKG2D in CD4(+) T cells specific for human cytomegalovirus. S??ez-Border??as, A., Gum??, M., Angulo, A., Bellosillo, B., Pende, D., L??pez-Botet, M. Eur. J. Immunol. (2006)
- Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. Cerboni, C., Neri, F., Casartelli, N., Zingoni, A., Cosman, D., Rossi, P., Santoni, A., Doria, M. J. Gen. Virol. (2007)
- NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients. Maccalli, C., Nonaka, D., Piris, A., Pende, D., Rivoltini, L., Castelli, C., Parmiani, G. Clin. Cancer Res. (2007)
- NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting. McGilvray, R.W., Eagle, R.A., Watson, N.F., Al-Attar, A., Ball, G., Jafferji, I., Trowsdale, J., Durrant, L.G. Clin. Cancer Res. (2009)
- Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Groh, V., Wu, J., Yee, C., Spies, T. Nature (2002)
- Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. Welte, S.A., Sinzger, C., Lutz, S.Z., Singh-Jasuja, H., Sampaio, K.L., Eknigk, U., Rammensee, H.G., Steinle, A. Eur. J. Immunol. (2003)
- Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate. Armeanu, S., Bitzer, M., Lauer, U.M., Venturelli, S., Pathil, A., Krusch, M., Kaiser, S., Jobst, J., Smirnow, I., Wagner, A., Steinle, A., Salih, H.R. Cancer Res. (2005)
- MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. Girlanda, S., Fortis, C., Belloni, D., Ferrero, E., Ticozzi, P., Sciorati, C., Tresoldi, M., Vicari, A., Spies, T., Groh, V., Caligaris-Cappio, F., Ferrarini, M. Cancer Res. (2005)
- BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia. Boissel, N., Rea, D., Tieng, V., Dulphy, N., Brun, M., Cayuela, J.M., Rousselot, P., Tamouza, R., Le Bouteiller, P., Mahon, F.X., Steinle, A., Charron, D., Dombret, H., Toubert, A. J. Immunol. (2006)
- Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. Nowbakht, P., Ionescu, M.C., Rohner, A., Kalberer, C.P., Rossy, E., Mori, L., Cosman, D., De Libero, G., Wodnar-Filipowicz, A. Blood (2005)
- Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains. Spreu, J., Stehle, T., Steinle, A. J. Immunol. (2006)
- The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Glienke, J., Sobanov, Y., Brostjan, C., Steffens, C., Nguyen, C., Lehrach, H., Hofer, E., Francis, F. Immunogenetics (1998)
- Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. Eleme, K., Taner, S.B., Onfelt, B., Collinson, L.M., McCann, F.E., Chalupny, N.J., Cosman, D., Hopkins, C., Magee, A.I., Davis, D.M. J. Exp. Med. (2004)
- ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. Sutherland, C.L., Rabinovich, B., Chalupny, N.J., Brawand, P., Miller, R., Cosman, D. Blood (2006)
- Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. Poggi, A., Prevosto, C., Massaro, A.M., Negrini, S., Urbani, S., Pierri, I., Saccardi, R., Gobbi, M., Zocchi, M.R. J. Immunol. (2005)
- Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium. Vankayalapati, R., Garg, A., Porgador, A., Griffith, D.E., Klucar, P., Safi, H., Girard, W.M., Cosman, D., Spies, T., Barnes, P.F. J. Immunol. (2005)
- Interleukin-15 activates human natural killer cells to clear the intestinal protozoan cryptosporidium. Dann, S.M., Wang, H.C., Gambarin, K.J., Actor, J.K., Robinson, P., Lewis, D.E., Caillat-Zucman, S., White, A.C. J. Infect. Dis. (2005)
- Transcriptional Regulation of ULBP1, a Human Ligand of the NKG2D Receptor. L??pez-Soto, A., Qui??ones-Lombra??a, A., L??pez-Arbes??, R., L??pez-Larrea, C., Gonz??lez, S. J. Biol. Chem. (2006)
- Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. McFarland, B.J., Kortemme, T., Yu, S.F., Baker, D., Strong, R.K. Structure (Camb.) (2003)
- Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Conejo-Garcia, J.R., Benencia, F., Courreges, M.C., Khang, E., Zhang, L., Mohamed-Hadley, A., Vinocur, J.M., Buckanovich, R.J., Thompson, C.B., Levine, B., Coukos, G. Cancer Biol. Ther. (2003)
- Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. Schreiner, B., Voss, J., Wischhusen, J., Dombrowski, Y., Steinle, A., Lochmüller, H., Dalakas, M., Melms, A., Wiendl, H. FASEB J. (2006)
- Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma. Raffaghello, L., Prigione, I., Airoldi, I., Camoriano, M., Levreri, I., Gambini, C., Pende, D., Steinle, A., Ferrone, S., Pistoia, V. Neoplasia (2004)
- Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Radaev, S., Rostro, B., Brooks, A.G., Colonna, M., Sun, P.D. Immunity (2001)
- Genomic organization and evolution of the ULBP genes in cattle. Larson, J.H., Marron, B.M., Beever, J.E., Roe, B.A., Lewin, H.A. BMC Genomics (2006)
- Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease. Azimi, N., Jacobson, S., Tanaka, Y., Corey, L., Groh, V., Spies, T. Immunogenetics (2006)
- NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. Saikali, P., Antel, J.P., Newcombe, J., Chen, Z., Freedman, M., Blain, M., Cayrol, R., Prat, A., Hall, J.A., Arbour, N. J. Neurosci. (2007)
- TNFalpha stimulates NKG2D-mediated lytic activity of acute myeloid leukemic cells. Guilloton, F., de Thonel, A., Jean, C., Demur, C., Mansat-De Mas, V., Laurent, G., Quillet-Mary, A. Leukemia (2005)
- Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Waldhauer, I., Steinle, A. Cancer Res. (2006)
- Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Castriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., Moretta, A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival. Mincheva-Nilsson, L., Nagaeva, O., Chen, T., Stendahl, U., Antsiferova, J., Mogren, I., Hernestål, J., Baranov, V. J. Immunol. (2006)
- Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells. Schrama, D., Terheyden, P., Otto, K., Kämmerer, U., Bröcker, E.B., Lühder, F., Cosman, D., Andersen, M.H., Becker, J.C. Eur. J. Immunol. (2006)
- Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. Bacon, L., Eagle, R.A., Meyer, M., Easom, N., Young, N.T., Trowsdale, J. J. Immunol. (2004)
- Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D. Forte, P., Lilienfeld, B.G., Baumann, B.C., Seebach, J.D. J. Immunol. (2005)
- Differential expression of inhibitory and activating CD94/NKG2 receptors on NK cell clones. Brostjan, C., Bellón, T., Sobanov, Y., López-Botet, M., Hofer, E. J. Immunol. Methods (2002)
- Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J.H., Lanier, L.L., Spies, T. Science (1999)
- NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Upshaw, J.L., Arneson, L.N., Schoon, R.A., Dick, C.J., Billadeau, D.D., Leibson, P.J. Nat. Immunol. (2006)