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de Jong, K.P. et al.

de Jong, Brouwers, van Veen, Brinker, de Vries, Daemen, Scherphof, Slooff,

Serum obtained from rats after partial hepatectomy enhances growth of cultured colon carcinoma cells.

Tumour-bearing rats were randomized to a 70% partial hepatectomy or a sham operation. At days 1, 3 or 14, portal and systemic serum was obtained and colon carcinoma cells were cultured in the presence of 5, 10, 20 or 50% serum. Proliferation and epidermal growth factor receptor (EGFr) expression was measured in tumour cells. Proliferation was 25-40% higher in tumour cells cultured with portal serum after hepatectomy than after sham operation when using serum obtained at day 3, but not days 1 and 14 after operation. In cultures with serum obtained at day 14 after operation CC 531 cells showed a 30% higher proliferation rate with systemic hepatectomy serum than CC 531 cells with sham systemic serum. These effects were not mediated by a change in EGFr mRNA and protein levels as the used colon carcinoma cells did not reveal EGFr activity by any of the three detection methods used.[1]

References

Serum obtained from rats after partial hepatectomy enhances growth of cultured colon carcinoma cells. de Jong, K.P., Brouwers, M.A., van Veen, M.L., Brinker, M., de Vries, E.G., Daemen, T., Scherphof, G.L., Slooff, M.J. Invasion Metastasis (1998) [Pubmed]

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