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Gene Review

Egfr  -  epidermal growth factor receptor

Rattus norvegicus

Synonyms: ERBB1, ErbB-1, Errp
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Disease relevance of Egfr


Psychiatry related information on Egfr


High impact information on Egfr


Chemical compound and disease context of Egfr


Biological context of Egfr


Anatomical context of Egfr


Associations of Egfr with chemical compounds


Physical interactions of Egfr


Enzymatic interactions of Egfr

  • EGFR and phosphorylated ERK significantly declined from 5 to 20 weeks (P<0.05) [29].

Regulatory relationships of Egfr


Other interactions of Egfr


Analytical, diagnostic and therapeutic context of Egfr


  1. CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Schattenberg, J.M., Wang, Y., Rigoli, R.M., Koop, D.R., Czaja, M.J. Hepatology (2004) [Pubmed]
  2. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. Schäfer, B., Marg, B., Gschwind, A., Ullrich, A. J. Biol. Chem. (2004) [Pubmed]
  3. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Correa-Meyer, E., Pesce, L., Guerrero, C., Sznajder, J.I. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  4. PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation. Mendez, M., LaPointe, M.C. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  5. HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line. Scoles, D.R., Qin, Y., Nguyen, V., Gutmann, D.H., Pulst, S.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Specific involvement of G(alphai2) with epidermal growth factor receptor signaling in rat hepatocytes, and the inhibitory effect of chronic ethanol. Zhang, B.H., Ho, V., Farrell, G.C. Biochem. Pharmacol. (2001) [Pubmed]
  7. Time-dependent alteration of epidermal growth factor receptor in rat stomach by ethanol feeding. Wang, S.L., Feng, J., Wu-Wang, C.Y. Toxicol. Lett. (1997) [Pubmed]
  8. Effects of matrix metalloproteinase inhibitor on LPS-induced goblet cell metaplasia. Kim, J.H., Lee, S.Y., Bak, S.M., Suh, I.B., Lee, S.Y., Shin, C., Shim, J.J., In, K.H., Kang, K.H., Yoo, S.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  9. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Cho, H.S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney, D.W., Leahy, D.J. Nature (2003) [Pubmed]
  10. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Daub, H., Weiss, F.U., Wallasch, C., Ullrich, A. Nature (1996) [Pubmed]
  11. Changes in retinal cell fate induced by overexpression of EGF receptor. Lillien, L. Nature (1995) [Pubmed]
  12. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Weiner, D.B., Liu, J., Cohen, J.A., Williams, W.V., Greene, M.I. Nature (1989) [Pubmed]
  13. Astrocyte mitogen inhibitor related to epidermal growth factor receptor. Nieto-Sampedro, M. Science (1988) [Pubmed]
  14. Suppression of ovarian cancer cell tumorigenicity and evasion of Cisplatin resistance using a truncated epidermal growth factor receptor in a rat model. Chan, J.K., Pham, H., You, X.J., Cloven, N.G., Burger, R.A., Rose, G.S., Van Nostrand, K., Korc, M., Disaia, P.J., Fan, H. Cancer Res. (2005) [Pubmed]
  15. Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Thomas, W.G., Brandenburger, Y., Autelitano, D.J., Pham, T., Qian, H., Hannan, R.D. Circ. Res. (2002) [Pubmed]
  16. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Kagiyama, S., Eguchi, S., Frank, G.D., Inagami, T., Zhang, Y.C., Phillips, M.I. Circulation (2002) [Pubmed]
  17. Role of epidermal growth factor receptor transactivation in PPAR gamma-dependent suppression of Helicobacter pylori interference with gastric mucin synthesis. Slomiany, B.L., Slomiany, A. Inflammopharmacology. (2004) [Pubmed]
  18. Intratumoral delivery of boronated epidermal growth factor for neutron capture therapy of brain tumors. Yang, W., Barth, R.F., Adams, D.M., Soloway, A.H. Cancer Res. (1997) [Pubmed]
  19. Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor. Murasawa, S., Mori, Y., Nozawa, Y., Gotoh, N., Shibuya, M., Masaki, H., Maruyama, K., Tsutsumi, Y., Moriguchi, Y., Shibazaki, Y., Tanaka, Y., Iwasaka, T., Inada, M., Matsubara, H. Circ. Res. (1998) [Pubmed]
  20. Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells. Konishi, A., Berk, B.C. J. Biol. Chem. (2003) [Pubmed]
  21. The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95. Reinehr, R., Becker, S., Höngen, A., Haüssinger, D. J. Biol. Chem. (2004) [Pubmed]
  22. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo, Y.S., Cheng, J.Z., Jin, G.F., Gutkind, J.S., Hellmich, M.R., Townsend, C.M. J. Biol. Chem. (2002) [Pubmed]
  23. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Gardner, O.S., Dewar, B.J., Earp, H.S., Samet, J.M., Graves, L.M. J. Biol. Chem. (2003) [Pubmed]
  24. Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. Hur, E.M., Park, Y.S., Lee, B.D., Jang, I.H., Kim, H.S., Kim, T.D., Suh, P.G., Ryu, S.H., Kim, K.T. J. Biol. Chem. (2004) [Pubmed]
  25. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. Sasaoka, T., Langlois, W.J., Leitner, J.W., Draznin, B., Olefsky, J.M. J. Biol. Chem. (1994) [Pubmed]
  26. Effect of epidermal growth factor on placental amino acid transport and regulation of epidermal growth factor receptor expression of hepatocyte in rat. Masuyama, H., Hiramatsu, Y., Kudo, T. Journal of perinatal medicine. (1996) [Pubmed]
  27. Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases. Palmer, H.J., Tuzon, C.T., Paulson, K.E. J. Biol. Chem. (1999) [Pubmed]
  28. SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation. Goldshmit, Y., Walters, C.E., Scott, H.J., Greenhalgh, C.J., Turnley, A.M. J. Biol. Chem. (2004) [Pubmed]
  29. Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Kagiyama, S., Qian, K., Kagiyama, T., Phillips, M.I. Hypertension (2003) [Pubmed]
  30. Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts. Wang, Y.Z., Bonner, J.C. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  31. Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor. Iwasaki, H., Eguchi, S., Ueno, H., Marumo, F., Hirata, Y. Endocrinology (1999) [Pubmed]
  32. Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts. Purdom, S., Chen, Q.M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  33. Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. Abdelmohsen, K., Gerber, P.A., von Montfort, C., Sies, H., Klotz, L.O. J. Biol. Chem. (2003) [Pubmed]
  34. Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor. Bokemeyer, D., Schmitz, U., Kramer, H.J. Kidney Int. (2000) [Pubmed]
  35. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo, S.J., Carreras, I., Panchenko, M.V., Stone, P.J., Nugent, M.A., Foster, J.A., Panchenko, M.P. J. Biol. Chem. (2002) [Pubmed]
  36. The phyto-chemical (-)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1. Fu, Y., Chen, A. Biochem. Pharmacol. (2006) [Pubmed]
  37. Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation. Kim, Y.R., Cha, H.Y., Lim, K., Hwang, B.D., Hoe, K.L., Namgung, U., Park, S.K. Exp. Mol. Med. (2003) [Pubmed]
  38. EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. Voisin, L., Foisy, S., Giasson, E., Lambert, C., Moreau, P., Meloche, S. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  39. Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. Ishii, M., Vroman, B., LaRusso, N.F. Gastroenterology (1990) [Pubmed]
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