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Inflammatory thoughts about glioma gene therapy.

Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256-1263).[1]

References

  1. Inflammatory thoughts about glioma gene therapy. Kielian, T., Hickey, W.F. Nat. Med. (1999) [Pubmed]
 
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