Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning.
Here we show that the Drosophila homologue of Lissencephaly-1, DLis-1, acts together with Bicaudal-D (Bic-D), Egalitarian (Egl), dynein and microtubules to determine oocyte identity. DLis-1 is further required for nurse-cell-to-oocyte transport during oocyte growth, and for the positioning of the nucleus in the oocyte. Immunostaining of DLis-1 protein reveals a cortical localization that is independent of microtubules. DLis-1 may function in this position as a cortical anchor for the other nuclear-localization factors. DLis-1 and Bic-D are further required for nuclear localization in the developing nervous system, indicating that homologues of Bic-D, dynein and Egl-like proteins may also be involved in vertebrate neural migration and that their absence may cause a Miller-Dieker-like lissencephaly.[1]References
- Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Swan, A., Nguyen, T., Suter, B. Nat. Cell Biol. (1999) [Pubmed]
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