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Gene Review

Dhc64C  -  Dynein heavy chain 64C

Drosophila melanogaster

Synonyms: CD, CG7507, Cdhc, DHC, DHC64C, ...
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Disease relevance of Dhc64C

  • Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte [1].
  • Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia [2].
  • Interactions between TcTex-1 and a diverse set of proteins such as the dynein intermediate chain, Fyn, DOC2, FIP1, the poliovirus receptor, CD155, and the rhodopsin cytoplasmic tail have been reported; yet, despite the broad range of targets, a consensus binding sequence remains uncertain [3].

High impact information on Dhc64C


Biological context of Dhc64C


Anatomical context of Dhc64C


Associations of Dhc64C with chemical compounds


Other interactions of Dhc64C

  • Furthermore, we show that a mutation that was previously isolated as a suppressor of the Glued mutation is an allele of Dhc64C [9].
  • 8. Far-UV CD and fluorescence spectra demonstrate that pH-dissociated LC8 retains native secondary and tertiary structures, while the diminished near-UV CD signal shows loss of quaternary structure [15].
  • Here, we use mutations in the dynein heavy chain gene to impair the motor's function, and employ biophysical measurements to demonstrate that cytoplasmic dynein is responsible for the minus end motion of bidirectionally moving lipid droplets in early Drosophila embryos [16].
  • A smaller but reproducible change in the CD spectra was observed upon Tctex-1 binding as well [17].
  • However, only two kinds of mechanochemical motor proteins, kinesin and brain dynein, had been identified as transporters of membranous organelles in mammalian neurons [18].

Analytical, diagnostic and therapeutic context of Dhc64C


  1. Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte. Ferree, P.M., Frydman, H.M., Li, J.M., Cao, J., Wieschaus, E., Sullivan, W. PLoS Pathog. (2005) [Pubmed]
  2. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. Zhang, Y.J., O'Neal, W.K., Randell, S.H., Blackburn, K., Moyer, M.B., Boucher, R.C., Ostrowski, L.E. J. Biol. Chem. (2002) [Pubmed]
  3. Crystal structure of dynein light chain TcTex-1. Williams, J.C., Xie, H., Hendrickson, W.A. J. Biol. Chem. (2005) [Pubmed]
  4. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Heald, R., Tournebize, R., Blank, T., Sandaltzopoulos, R., Becker, P., Hyman, A., Karsenti, E. Nature (1996) [Pubmed]
  5. Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Liu, Z., Steward, R., Luo, L. Nat. Cell Biol. (2000) [Pubmed]
  6. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos. Sharp, D.J., Rogers, G.C., Scholey, J.M. Nat. Cell Biol. (2000) [Pubmed]
  7. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila. Robinson, J.T., Wojcik, E.J., Sanders, M.A., McGrail, M., Hays, T.S. J. Cell Biol. (1999) [Pubmed]
  8. Cytoplasmic dynein function is essential in Drosophila melanogaster. Gepner, J., Li, M., Ludmann, S., Kortas, C., Boylan, K., Iyadurai, S.J., McGrail, M., Hays, T.S. Genetics (1996) [Pubmed]
  9. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. McGrail, M., Gepner, J., Silvanovich, A., Ludmann, S., Serr, M., Hays, T.S. J. Cell Biol. (1995) [Pubmed]
  10. Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Martin, M., Iyadurai, S.J., Gassman, A., Gindhart, J.G., Hays, T.S., Saxton, W.M. Mol. Biol. Cell (1999) [Pubmed]
  11. A family of dynein genes in Drosophila melanogaster. Rasmusson, K., Serr, M., Gepner, J., Gibbons, I., Hays, T.S. Mol. Biol. Cell (1994) [Pubmed]
  12. Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila. Ghosh-Roy, A., Kulkarni, M., Kumar, V., Shirolikar, S., Ray, K. Mol. Biol. Cell (2004) [Pubmed]
  13. Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Swan, A., Nguyen, T., Suter, B. Nat. Cell Biol. (1999) [Pubmed]
  14. Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein. Shimizu, T., Toyoshima, Y.Y., Edamatsu, M., Vale, R.D. Biochemistry (1995) [Pubmed]
  15. Dimerization and folding of LC8, a highly conserved light chain of cytoplasmic dynein. Barbar, E., Kleinman, B., Imhoff, D., Li, M., Hays, T.S., Hare, M. Biochemistry (2001) [Pubmed]
  16. Dynein-mediated cargo transport in vivo. A switch controls travel distance. Gross, S.P., Welte, M.A., Block, S.M., Wieschaus, E.F. J. Cell Biol. (2000) [Pubmed]
  17. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Makokha, M., Hare, M., Li, M., Hays, T., Barbar, E. Biochemistry (2002) [Pubmed]
  18. Kinesin family in murine central nervous system. Aizawa, H., Sekine, Y., Takemura, R., Zhang, Z., Nangaku, M., Hirokawa, N. J. Cell Biol. (1992) [Pubmed]
  19. Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte. Li, M., McGrail, M., Serr, M., Hays, T.S. J. Cell Biol. (1994) [Pubmed]
  20. A fertility region on the Y chromosome of Drosophila melanogaster encodes a dynein microtubule motor. Gepner, J., Hays, T.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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