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Gene Review

Lis-1  -  Lissencephaly-1

Drosophila melanogaster

Synonyms: CG8440, D-Lis1, DLIS-1, DLIS1, DLis-1, ...
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High impact information on Lis-1


Biological context of Lis-1

  • In addition, we develop an improved time-lapse video microscopy technique that allows live imaging of GFP-Lis1, GFP-Rod checkpoint protein, green fluorescent protein (GFP)-labeled chromosomes, or GFP-labeled mitotic spindle dynamics in neuroblasts within whole larval brain explants [3].

Anatomical context of Lis-1

  • Immunostaining of DLis-1 protein reveals a cortical localization that is independent of microtubules [2].
  • LIS1 is hypothesized to regulate nuclear movement in migrating neurons through interactions with the cytoskeleton, while the alpha-subunits, whose structure is known, contain a trypsin-like triad within the framework of a unique tertiary fold [4].

Other interactions of Lis-1


  1. Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Liu, Z., Steward, R., Luo, L. Nat. Cell Biol. (2000) [Pubmed]
  2. Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Swan, A., Nguyen, T., Suter, B. Nat. Cell Biol. (1999) [Pubmed]
  3. Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Siller, K.H., Serr, M., Steward, R., Hays, T.S., Doe, C.Q. Mol. Biol. Cell (2005) [Pubmed]
  4. Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome. Sheffield, P.J., Garrard, S., Caspi, M., Aoki, J., Arai, H., Derewenda, U., Inoue, K., Suter, B., Reiner, O., Derewenda, Z.S. Proteins (2000) [Pubmed]
  5. The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration. Lei, Y., Warrior, R. Dev. Biol. (2000) [Pubmed]
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