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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN.[1]

References

  1. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. Shimizu, K., Okada, M., Takano, A., Nagai, K. FEBS Lett. (1999) [Pubmed]
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