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Eurotium (Aspergillus) repens metabolites and their biological activity.

Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities--echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 microgram/ml, caused 50% mor7 tality in Artemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50% growth inhibition at a concentration of 0.1 microgram/ml.[1]

References

  1. Eurotium (Aspergillus) repens metabolites and their biological activity. Podojil, M., Sedmera, P., Vokoun, J., Betina, V., Baráthová, H., Duracková, Z., Horáková, K., Nemec, P. Folia Microbiol. (Praha) (1978) [Pubmed]
 
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