Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues.
Cardiotrophin-1 ( CT-1) originally was discovered as a factor that can induce hypertrophy of cardiac myocytes, both in vitro and in vivo. Subsequently, CT-1 has been shown to have a wide variety of different effects on cardiac and noncardiac, cells including the ability to stimulate the survival of both cardiac and neuronal cells. Like other members of the interleukin-6 family of cytokines, CT-1 stimulates both the p42/ p44 mitogen-activated protein kinase pathway and the Janus-activated kinase/signal transducers and activators of transcription pathway. Interestingly, whilst activation of the p42/ p44 mitogen- activated protein kinase pathway is necessary for the survival- promoting effects of CT-1 in cardiac cells, it is not required for its hypertrophic effect, which is likely to involve activation of the Janus-activated kinase/signal transducer and activator of transcription-3 pathway. CT-1, therefore, may be of use as a novel cardioprotective agent, particularly if its hypertrophic effect can be specifically inhibited.[1]References
- Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues. Latchman, D.S. Pharmacol. Ther. (2000) [Pubmed]
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