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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation.

The misuse of benzodiazepines (BNZ)s may result in serious side effects. Three cases of convulsive status epilepticus (CSE) following abrupt discontinuation of long-term use of 25 mg of lorazepam in one patient and more than 20 mg of flunitrazepam in two patients are presented; they were non-epileptics and free of other high-risk factors for seizures. A favorable outcome for all three cases was noted. They remain free of seizures without antiepileptic treatment. Nevertheless, because of the extensive use of benzodiazepines, such rare high-risk side effects must be emphasized.[1]


  1. Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation. Gatzonis, S.D., Angelopoulos, E.K., Daskalopoulou, E.G., Mantouvalos, V., Chioni, A., Zournas, C., Siafakas, A. Drug and alcohol dependence. (2000) [Pubmed]
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