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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An alternative pathway of nitric oxide production by rat astrocytes requires specific antigen and T cell contact.

In the present study, we observed an alternative pathway in which nitric oxide (NO) production by rat astrocytes requires specific antigen and cell-cell contact. NO production by astrocytes was significantly inhibited by antibodies against CD40L, B7-1 or B7-2. Astrocyte-derived NO inhibited T cell proliferation and induced T cell apoptosis. In contrast, augmented astrocyte proliferation was correlated to the levels of NO production by astrocytes, implicating a role of NO in regulating local immune responses in the central nervous system. These results suggest that T cell-astrocyte interactions may regulate local immune responses via the NO pathway and influence the fate of infiltrating T cells.[1]

References

  1. An alternative pathway of nitric oxide production by rat astrocytes requires specific antigen and T cell contact. Xiao, B.G., Xu, L.Y., Yang, J.S., Huang, Y.M., Link, H. Neurosci. Lett. (2000) [Pubmed]
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