Disease relevance of Cd40lg

• METHODS: We constructed Adv-shCD40L-IRES2-CTLA4Ig, a replication-defective adenovirus carrying genes encoding human CD40L and CTLA4Ig [1].
• Adenovirus-mediated CD40 ligand gene therapy in a rat model of orthotopic hepatocellular carcinoma [2].
• Previously we found that CD40 ligand (CD154) is functionally expressed on peritoneal macrophages during continuous ambulatory peritoneal dialysis peritonitis [3].

Psychiatry related information on Cd40lg

• In addition, this may lead to the generation of anti-inflammatory mediators that support defense mechanisms against root resorption, which depend on the type of immune response that is induced regarding CD40-CD40L expression [4].

High impact information on Cd40lg

• In vitro infection of a rat HCC cell line (McA-RH7777) with adenoviral vector expressing CD40 ligand (AdCMVmCD40L) induced CD40L expression in a dose-dependent manner [2].
• On day 0, the mice received 3 Gy total body irradiation (TBI), an intravenous injection of unseparated bone marrow (BM) harvested from F344 rats, and an intraperitoneal injection of hamster antimouse CD40L mAb, MR1 [5].
• Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade [6].
• BACKGROUND: Blockade of the CD40-CD40L pathway results in long-term allograft survival but does not prevent chronic rejection [6].
• GM-CSF in association with tumor necrosis factor-alpha or IL-4, or cell-associated CD40-ligand, all known to be potent stimulators of B7 expression on other dendritic cells, did not restore B7 expression by TiDCs [7].

Biological context of Cd40lg

• Nucleotide sequence of the rat CD40 ligand [8].
• Suppression of EAMG is accompanied by down-regulation of the costimulatory factor CD40L and up-regulation of CTLA-4, a key negative immunomodulator [9].

Anatomical context of Cd40lg

• Rat lymphocytes activated ex vivo with phorbol 12-myristate, 13-acetate increased K(f,c) in isolated lungs independently of I/R, and this increase was prevented by pretreating lungs with anti-CD40 [10].
• NO production by astrocytes was significantly inhibited by antibodies against CD40L, B7-1 or B7-2 [11].
• In the tension side, some cells of the cellular cementum expressed CD40L [4].
• The expression of two genes related to B-cell responses, B-lymphocyte chemoattractant, and CD40 ligand, showed a similar time course to that of the immunoglobulin kappa chain gene [12].

Associations of Cd40lg with chemical compounds

• Additionally, LPS-treated, but not CD40L-treated BMDC secreted TNF-alpha into the supernatant [13].
• The majority of rats (70%) treated with CD40L at the onset of dexamethasone immunosuppression were protected against PCP [14].

Other interactions of Cd40lg

• The results showed that the expression of CD40, CD40L and matrix metalloproteinase were higher in As group than those in control group [15].
• It is known that parasites produce some types of molecule that mimic host molecules such as CD40 ligand, TGF-beta and macrophage migration inhibitory factor [16].

Analytical, diagnostic and therapeutic context of Cd40lg

• Prolongation of renal allograft survival in rats by replication-defective recombinant adenovirus-mediated coexpression of CD40L and CTLA4Ig [1].
• The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin [17].
• BACKGROUND: The authors' aim was to evaluate the efficacy of immunosuppression with monoclonal anti-CD40 ligand antibodies (aCD40L) or nonspecific polyclonal intravenous immunoglobulin (IVIG) in the pig-to-rat islet xenotransplantation model [17].
• Anti-CD154 (CD40L) prevents recurrence of diabetes in islet isografts in the DR-BB rat [18].
• BACKGROUND: The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies induces tolerance or long-term acceptance in rat liver and heart allograft transplantation [19].

References