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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling.

In animal development, numerous cell-cell interactions are mediated by the GLP-1/LIN-12/NOTCH family of transmembrane receptors. These proteins function in a signaling pathway that appears to be conserved from nematodes to humans. We show here that the aph-2 gene is a new component of the GLP-1 signaling pathway in the early Caenorhabditis elegans embryo, and that proteins with sequence similarity to the APH-2 protein are found in Drosophila and vertebrates. During the GLP-1-mediated cell interactions in the C. elegans embryo, APH-2 is associated with the cell surfaces of both the signaling, and the responding, blastomeres. Analysis of chimeric embryos that are composed of aph-2(+) and aph-2(-) blastomeres suggests that aph-2(+) function may be provided by either the signaling or responding blastomere.[1]

References

  1. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Goutte, C., Hepler, W., Mickey, K.M., Priess, J.R. Development (2000) [Pubmed]
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