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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aph-2  -  Protein APH-2

Caenorhabditis elegans

 
 
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High impact information on aph-2

  • Analysis of chimeric embryos that are composed of aph-2(+) and aph-2(-) blastomeres suggests that aph-2(+) function may be provided by either the signaling or responding blastomere [1].
  • In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also display an egg-laying defect [2].

References

  1. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Goutte, C., Hepler, W., Mickey, K.M., Priess, J.R. Development (2000) [Pubmed]
  2. APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Levitan, D., Yu, G., St George Hyslop, P., Goutte, C. Dev. Biol. (2001) [Pubmed]
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