The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

aph-2  -  Protein APH-2

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on aph-2

  • Analysis of chimeric embryos that are composed of aph-2(+) and aph-2(-) blastomeres suggests that aph-2(+) function may be provided by either the signaling or responding blastomere [1].
  • In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also display an egg-laying defect [2].


  1. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Goutte, C., Hepler, W., Mickey, K.M., Priess, J.R. Development (2000) [Pubmed]
  2. APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Levitan, D., Yu, G., St George Hyslop, P., Goutte, C. Dev. Biol. (2001) [Pubmed]
WikiGenes - Universities