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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The first directed reduction of beta-alkoxy ketones to anti-1,3-diol monoethers: identification of spectator and director alkoxy groups.

A new reduction procedure for the stereoselective reduction of certain beta-alkoxy ketones is described. The method relies upon electron-transfer reduction using samarium diiodide in THF with MeOH as an additive. Reduction is facile for a number of alkoxy groups that can complex samarium effectively but is not observed with TBS or benzyl protecting groups. Experiments with deuterated methanol show that the stereoselectivity arises from protonation of a samarium carbanion intermediate.[1]

References

  1. The first directed reduction of beta-alkoxy ketones to anti-1,3-diol monoethers: identification of spectator and director alkoxy groups. Keck, G.E., Wager, C.A. Org. Lett. (2000) [Pubmed]
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