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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

The cytokine interleukin-10 ( IL-10) has shown promise in clinical trials for treatment of inflammatory bowel disease (IBD). Using two mouse models, we show that the therapeutic dose of IL-10 can be reduced by localized delivery of a bacterium genetically engineered to secrete the cytokine. Intragastric administration of IL-10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10(-/-) mice. This approach may lead to better methods for cost-effective and long-term management of IBD in humans.[1]

References

  1. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., Remaut, E. Science (2000) [Pubmed]
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