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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Increased oxidative stress in kwashiorkor.

To test the hypothesis that kwashiorkor is associated with increased oxidative stress, urinary concentrations of 2 oxidized amino acids, o,o '-dityrosine and ortho -tyrosine, were measured by gas chromatography-mass spectrometry. Children with kwashiorkor, with or without infection, had a 3- to 7-fold increase in urinary o,o '-dityrosine and a 1.5- to 2-fold increase in ortho -tyrosine when compared with well-nourished children. This observation raises the possibility that oxidative damage to proteins and other biologic targets plays a role in the clinical manifestations of kwashiorkor.[1]


  1. Increased oxidative stress in kwashiorkor. Manary, M.J., Leeuwenburgh, C., Heinecke, J.W. J. Pediatr. (2000) [Pubmed]
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