Increased oxidative stress in kwashiorkor.
To test the hypothesis that kwashiorkor is associated with increased oxidative stress, urinary concentrations of 2 oxidized amino acids, o,o '-dityrosine and ortho -tyrosine, were measured by gas chromatography-mass spectrometry. Children with kwashiorkor, with or without infection, had a 3- to 7-fold increase in urinary o,o '-dityrosine and a 1.5- to 2-fold increase in ortho -tyrosine when compared with well-nourished children. This observation raises the possibility that oxidative damage to proteins and other biologic targets plays a role in the clinical manifestations of kwashiorkor.[1]References
- Increased oxidative stress in kwashiorkor. Manary, M.J., Leeuwenburgh, C., Heinecke, J.W. J. Pediatr. (2000) [Pubmed]
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