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Disease relevance of Kwashiorkor


Psychiatry related information on Kwashiorkor


High impact information on Kwashiorkor

  • Although glutathione, known to participate in LTC4 synthesis, was subnormal in erythrocytes of all malnourished patients, whole-blood LTC4 synthesis was higher in kwashiorkor patients than in controls (28.1 [5.0] ng/mL; p < 0.05), and close to control values (9.8 [1.5] ng/mL) in marasmic children [7].
  • Whole blood LTE4 synthesis was increased in kwashiorkor patients by a factor of 3.5 (p < 0.01) [7].
  • LTB4 synthesis, however, was greatly reduced in kwashiorkor patients (11.5 [2.4] vs 46.5 [6.4] ng/mL; p < 0.01) [7].
  • Urinary LTE4 excretion was significantly higher in patients with kwashiorkor than in controls (118.8 [SD 28.5] vs 31.1 [19.3] nmol/mol creatinine; p < 0.01) [7].
  • The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia [8].

Chemical compound and disease context of Kwashiorkor

  • This decrease in T3 was significantly (P less than 0-001) more pronounced in kwashiorkor of recent onset than in long-term P.C.M., a finding which suggests that impaired thyroxine (T4) monodeiodination in the liver was responsible for the fall in serum-T3 concentration rather than a reduction in the secretion of T3 by the thyroid [9].
  • Skin sores in kwashiorkor, pellagra, and vitamin B6 deficiency [10].
  • Postheparin serum lipolytic activities (hepatic and extrahepatic), serum free fatty acid, and triglyceride levels were measured in 16 kwashiorkor, 14 marasmic, and 14 control children [11].
  • Chloramphenicol binding to normal and kwashiorkor sera [12].
  • Serotonin metabolism in children with kwashiorkor [2].

Biological context of Kwashiorkor


Anatomical context of Kwashiorkor


Gene context of Kwashiorkor


Analytical, diagnostic and therapeutic context of Kwashiorkor


  1. Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment. Unterman, T.G., Vazquez, R.M., Slas, A.J., Martyn, P.A., Phillips, L.S. Am. J. Med. (1985) [Pubmed]
  2. Serotonin metabolism in children with kwashiorkor. Teotia, M., Teotia, S.P. Am. J. Clin. Nutr. (1975) [Pubmed]
  3. The clinical significance of disaccharide maldigestion. Gudmand-Høyer, E. Am. J. Clin. Nutr. (1994) [Pubmed]
  4. Some observations on the properties of precipitating antibody to Staphylococcus aureus in children with kwashiorkor. Olusi, S.O. Pediatr. Res. (1979) [Pubmed]
  5. Gastric emptying in children. IV. Studies on kwashiorkor and on marasmic kwashiorkor. Franco, V.H., Collares, E.F., Troncon, L.E. Arquivos de gastroenterologia. (1986) [Pubmed]
  6. A prospective 15-year follow-up study of kwashiorkor patients. Part II. Social circumstances, educational attainment and social adjustment. Moodie, A.D., Bowie, M.D., Mann, M.D., Hansen, J.D. S. Afr. Med. J. (1980) [Pubmed]
  7. Leukotrienes in the pathophysiology of kwashiorkor. Mayatepek, E., Becker, K., Gana, L., Hoffmann, G.F., Leichsenring, M. Lancet (1993) [Pubmed]
  8. The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Scott, J.M., Weir, D.G. Lancet (1981) [Pubmed]
  9. Triiodothyronine and thyroid-stimulating hormone in protein-calorie malnutrition in infants. Ingenbleek, Y., Beckers, C. Lancet (1975) [Pubmed]
  10. Skin sores in kwashiorkor, pellagra, and vitamin B6 deficiency. Van Winkle, L.J. Lancet (1980) [Pubmed]
  11. Studies on hepatic and extrahepatic lipoprotein lipases in protein-calorie malnutrition. Agbedana, E.O., Johnson, A.O., Taylor, G.O. Am. J. Clin. Nutr. (1979) [Pubmed]
  12. Chloramphenicol binding to normal and kwashiorkor sera. Buchanan, N., Van der Walt, L.A. Am. J. Clin. Nutr. (1977) [Pubmed]
  13. Clinical pharmacokinetics of the antituberculosis drugs. Holdiness, M.R. Clinical pharmacokinetics. (1984) [Pubmed]
  14. Acetanilide pharmacokinetics in kwashiorkor. Buchanan, N., Davis, M.D., Henderson, D.B., Mucklow, J.C., Rawlins, M.D. British journal of clinical pharmacology. (1980) [Pubmed]
  15. Observations on the mechanisms underlying the defective methylation of deoxyuridylate in kwashiorkor. Wickramasinghe, S.N., Litwinczuk, R.A., Akinyanju, O.O., Grange, A. Br. J. Haematol. (1983) [Pubmed]
  16. Gentamicin pharmacokinetics in kwashiorkor. Buchanan, N., Davis, M.D., Eyberg, C. British journal of clinical pharmacology. (1979) [Pubmed]
  17. Cefoxitin: intravenous pharmacokinetics and intramuscular bioavailability in kwashiorkor. Buchanan, N., Mithal, Y., Witcomb, M. British journal of clinical pharmacology. (1980) [Pubmed]
  18. Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. Velázquez, A., Terán, M., Báez, A., Gutiérrez, J., Rodríguez, R. Am. J. Clin. Nutr. (1995) [Pubmed]
  19. Febrile and plasma iron responses of rabbits injected with endogenous pyrogen from malnourished patients. Hoffman-Goetz, L., McFarlane, D., Bistrian, B.R., Blackburn, G.L. Am. J. Clin. Nutr. (1981) [Pubmed]
  20. Nitrosamine metabolism in kwashiorkor rats. Maduagwu, E.N., Frei, E., Frank, N., Spiegelhalder, B., Preussmann, R. Biochem. Pharmacol. (1983) [Pubmed]
  21. Reduction in vitro of red cell glutathione reproduces defects of cellular sodium transport seen in oedematous malnutrition. Forrester, T., Golden, M., Brand, S., Swales, J. European journal of clinical nutrition. (1990) [Pubmed]
  22. Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor. Dhansay, M.A., Benadé, A.J., Donald, P.R. Am. J. Clin. Nutr. (1991) [Pubmed]
  23. Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. Becker, K., Leichsenring, M., Gana, L., Bremer, H.J., Schirmer, R.H. Free Radic. Biol. Med. (1995) [Pubmed]
  24. Inflammatory mediators in children with protein-energy malnutrition. Sauerwein, R.W., Mulder, J.A., Mulder, L., Lowe, B., Peshu, N., Demacker, P.N., van der Meer, J.W., Marsh, K. Am. J. Clin. Nutr. (1997) [Pubmed]
  25. The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor. Akinyinka, O.O., Sowunmi, A., Honeywell, R., Renwick, A.G. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
  26. The role of retinol-binding protein in protein-calorie malnutrition. Ingenbleek, Y., Van Den Schrieck, H.G., De Nayer, P., De Visscher, M. Metab. Clin. Exp. (1975) [Pubmed]
  27. Free catecholamine excretion in the urine in normal infants and in those with marasmus or kwashiorkor. Graham, G.G., Placko, R.P. J. Pediatr. (1975) [Pubmed]
  28. Alpha 2 HS-glycoprotein levels in children with protein-energy malnutrition and infections. Abiodun, P.O., Olomu, I.N. J. Pediatr. Gastroenterol. Nutr. (1987) [Pubmed]
  29. The evaluation of serum leptin level and other hormonal parameters in children with severe malnutrition. Kilic, M., Taskin, E., Ustundag, B., Aygun, A.D. Clin. Biochem. (2004) [Pubmed]
  30. Selective deficiency of hepatic triglyceride lipase and hypertriglyceridaemia in kwashiorkor. Agbedana, E.O., Johnson, A.O., Taylor, G.O. Br. J. Nutr. (1979) [Pubmed]
  31. Amino acids, glucose and lactate concentrations in umbilical cord blood in relation to umbilical artery flow patterns. Karsdorp, V.H., van Vugt, J.M., Jakobs, C., Dekker, G.A., van Geijn, H.P. Eur. J. Obstet. Gynecol. Reprod. Biol. (1994) [Pubmed]
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