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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.

Pre-B cell receptor (pre-BCR) expression is critical for B lineage development. The signaling events initiated by the pre-BCR, however, remain poorly defined. We demonstrate that lipid rafts are the major functional compartment for human pre-B cell activation. A fraction of pre-BCR was constitutively raft associated, and receptor engagement enhanced this association. These events promoted Lyn activation and Igbeta phosphorylation and led to the generation of a raft-associated signaling module composed of tyrosine phosphorylated Lyn, Syk, BLNK, PI3K, Btk, VAV, and PLCgamma2. Formation of this module was essential for pre-BCR calcium signaling. Together, these observations directly link the previously identified genetic requirement for the components of this module in B lineage development with theirfunctional role(s) in human preBCR signaling.[1]

References

  1. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Guo, B., Kato, R.M., Garcia-Lloret, M., Wahl, M.I., Rawlings, D.J. Immunity (2000) [Pubmed]
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