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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine.

Central vein phlebitis and occlusion developed in a patient who was receiving immunosuppressive therapy with azathioprine (Imuran) and prednisone after renal transplantation. He had been well for 1 year before evidence of liver disease was noted; once begun, it progressed to hepatocellular failure in spite of a change in immunosuppressants from azathioprine to cyclophosphamide. Several known causes of venoocclusive disease and the possible causes in this patient are discussed.[1]


  1. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine. Marubbio, A.T., Danielson, B. Gastroenterology (1975) [Pubmed]
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