Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulates aging and metabolism, we restored daf-2 pathway signaling to only neurons, muscle, or intestine. Insulinlike signaling in neurons alone was sufficient to specify wild-type life-span, but muscle or intestinal signaling was not. However, restoring daf-2 pathway signaling to muscle rescued metabolic defects, thus decoupling regulation of life-span and metabolism. These findings point to the nervous system as a central regulator of animal longevity.[1]References
- Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Wolkow, C.A., Kimura, K.D., Lee, M.S., Ruvkun, G. Science (2000) [Pubmed]
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