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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Latitude-correlated genetic polymorphisms: selection or gene flow?

Latitude-correlated polymorphisms can be due to either selection-driven evolution or gene flow. To discriminate between them, we propose an approach that studies subpopulations springing from a single population that have lived for generations at different latitudes and have had a low genetic admixture. These requirements are fulfilled to a large extent by Ashkenazi and Sephardi Jews. The original population lived at a latitude of 35 degrees N, where the Sephardis still live. The Ashkenazis, however, moved to a latitude of 50 degrees N, starting about 10 centuries ago. The present study examines 3 latitude-correlated polymorphisms: PGP, PGM1, and AHSG. We found that PGP*2 and AHSG*2 alleles most likely underwent selection-driven evolution, but that PGM1*ts allele was not similarly affected. Since temperature might have been considered a reasonable selective factor, we also studied a population living at >800 m above sea level from Aosta Valley (Italy).[1]

References

  1. Latitude-correlated genetic polymorphisms: selection or gene flow? Ciminelli, B.M., Jodice, C., Scozzari, R., Corbo, R.M., Nahum, M., Pompei, F., Santachiara-Benerecetti, S.A., Santolamazza, C., Morpurgo, G.P., Modiano, G. Hum. Biol. (2000) [Pubmed]
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