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Gene Review

AHSG  -  alpha-2-HS-glycoprotein

Homo sapiens

Synonyms: A2HS, AHS, Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, ...
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Disease relevance of AHSG


Psychiatry related information on AHSG

  • The purpose of this study was to investigate the distribution of AHSG gene polymorphism in 235 Caucasian Italian patients with late-onset Alzheimer's disease (LOAD) and 235 age- and gender-matched healthy controls [7].

High impact information on AHSG

  • METHODS: We did a cross-sectional study in 312 stable patients on haemodialysis to analyse the inter-relation of AHSG and C-reactive protein (CRP) and their predictive effect on all-cause and cardiovascular mortality, over a period of 32 months [1].
  • Fetuin-A (alpha2-Heremans Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response [1].
  • Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation (mean IC50: 9.0 microL serum [SD 3.1] vs 7.5 [0.8] in short-term patients and 6.4 [2.6] in controls) [1].
  • In the present study, we have examined the chemotactic response of human peripheral blood monocytes and related polymorphonuclear leucocytes to three constituents of bone matrix: peptides from Type I collagen, alpha 2-HS glycoprotein, and osteocalcin (bone gla protein) [8].
  • The AHSG cDNA was utilized for mapping the AHSG gene to the 3q21----qter region of human chromosome 3 [9].

Chemical compound and disease context of AHSG


Biological context of AHSG


Anatomical context of AHSG


Associations of AHSG with chemical compounds


Other interactions of AHSG

  • TNF-alpha levels were negatively correlated with transferrin and AHSG levels [22].
  • Similarly, in R patients, AHSG levels tended to decrease (P = 0.0942) following IFN-alpha treatment [2].
  • Three members of the human cystatin gene superfamily, AHSG, HRG, and KNG, map within one megabase of genomic DNA at 3q27 [23].
  • The proteins, TF, PI, and AHSG proved to be especially rich in special genetically fixed variants and polymorphisms, and F13B proved to be a powerful genetic marker to distinguish human groups [24].
  • The present study examines 3 latitude-correlated polymorphisms: PGP, PGM1, and AHSG [25].

Analytical, diagnostic and therapeutic context of AHSG


  1. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Ketteler, M., Bongartz, P., Westenfeld, R., Wildberger, J.E., Mahnken, A.H., Böhm, R., Metzger, T., Wanner, C., Jahnen-Dechent, W., Floege, J. Lancet (2003) [Pubmed]
  2. Paradoxical alteration of acute-phase protein levels in patients with chronic hepatitis C treated with IFN-alpha2b. Kalabay, L., Nemesánszky, E., Csepregi, A., Pusztay, M., Dávid, K., Horváth, G., Ibrányi, E., Telegdy, L., Pár, A., Bíró, A., Fekete, B., Gervain, J., Horányi, M., Ribiczey, P., Csöndes, M., Kleiber, M., Walentin, S., Prohászka, Z., Füst, G. Int. Immunol. (2004) [Pubmed]
  3. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Dahlman, I., Eriksson, P., Kaaman, M., Jiao, H., Lindgren, C.M., Kere, J., Arner, P. Diabetologia (2004) [Pubmed]
  4. Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function. Lavebratt, C., Dungner, E., Hoffstedt, J. J. Lipid Res. (2005) [Pubmed]
  5. AHSG gene variant is associated with leanness among Swedish men. Lavebratt, C., Wahlqvist, S., Nordfors, L., Hoffstedt, J., Arner, P. Hum. Genet. (2005) [Pubmed]
  6. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. Reinehr, T., Roth, C.L. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  7. Genetic association of alpha2-Heremans-Schmid glycoprotein polymorphism with late-onset Alzheimer's disease in Italians. Geroldi, D., Minoretti, P., Bianchi, M., Di Vito, C., Reino, M., Bertona, M., Emanuele, E. Neurosci. Lett. (2005) [Pubmed]
  8. Recruitment of osteoclast precursors by purified bone matrix constituents. Malone, J.D., Teitelbaum, S.L., Griffin, G.L., Senior, R.M., Kahn, A.J. J. Cell Biol. (1982) [Pubmed]
  9. Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript. Lee, C.C., Bowman, B.H., Yang, F.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. Alpha hemolytic streptococcal infection during intensive treatment for acute myeloid leukemia: a report from the Children's cancer group study CCG-2891. Gamis, A.S., Howells, W.B., DeSwarte-Wallace, J., Feusner, J.H., Buckley, J.D., Woods, W.G. J. Clin. Oncol. (2000) [Pubmed]
  11. Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study. Rusiecki, J.A., Hou, L., Lee, W.J., Blair, A., Dosemeci, M., Lubin, J.H., Bonner, M., Samanic, C., Hoppin, J.A., Sandler, D.P., Alavanja, M.C. Int. J. Cancer (2006) [Pubmed]
  12. Cystatin domains in alpha-2-HS-glycoprotein and fetuin. Elzanowski, A., Barker, W.C., Hunt, L.T., Seibel-Ross, E. FEBS Lett. (1988) [Pubmed]
  13. CSF monoamine metabolites, cholinesterases and lactate in the adult hydrocephalus syndrome (normal pressure hydrocephalus) related to CSF hydrodynamic parameters. Malm, J., Kristensen, B., Ekstedt, J., Adolfsson, R., Wester, P. J. Neurol. Neurosurg. Psychiatr. (1991) [Pubmed]
  14. Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids. Brook, I., Foote, P.A. The Annals of otology, rhinology, and laryngology. (2004) [Pubmed]
  15. Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Srinivas, P.R., Wagner, A.S., Reddy, L.V., Deutsch, D.D., Leon, M.A., Goustin, A.S., Grunberger, G. Mol. Endocrinol. (1993) [Pubmed]
  16. Direct assignment of orosomucoid to human chromosome 9 and alpha 2HS-glycoprotein to chromosome 3 using human fetal liver x rat hepatoma hybrids. Cox, D.W., Francke, U. Hum. Genet. (1985) [Pubmed]
  17. Genetic polymorphisms of orosomucoid and alpha-2-HS-glycoprotein in a Philippine population. Umetsu, K., Yuasa, I., Nishimura, H., Sasaki, H., Suzuki, T. Hum. Hered. (1988) [Pubmed]
  18. Serum and plasma inhibit neutrophil stimulation by hydroxyapatite crystals. Evidence that serum alpha 2-HS glycoprotein is a potent and specific crystal-bound inhibitor. Terkeltaub, R.A., Santoro, D.A., Mandel, G., Mandel, N. Arthritis Rheum. (1988) [Pubmed]
  19. Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. Kalabay, L., Jakab, L., Prohászka, Z., Füst, G., Benkö, Z., Telegdy, L., Lörincz, Z., Závodszky, P., Arnaud, P., Fekete, B. European journal of gastroenterology & hepatology. (2002) [Pubmed]
  20. A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Siddiq, A., Lepretre, F., Hercberg, S., Froguel, P., Gibson, F. Diabetes (2005) [Pubmed]
  21. Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. Kalabay, L., Cseh, K., Pajor, A., Baranyi, E., Csákány, G.M., Melczer, Z., Speer, G., Kovács, M., Siller, G., Karádi, I., Winkler, G. Eur. J. Endocrinol. (2002) [Pubmed]
  22. Cytokine regulation of the acute-phase protein levels in multiple myeloma. Bíró, L., Domján, G., Falus, A., Jakab, L., Cseh, K., Kalabay, L., Tarkovács, G., Tresch, J., Malle, E., Kramer, J., Prohászka, Z., Jákó, J., Füst, G., Császár, A. Eur. J. Clin. Invest. (1998) [Pubmed]
  23. Three members of the human cystatin gene superfamily, AHSG, HRG, and KNG, map within one megabase of genomic DNA at 3q27. Rizzu, P., Baldini, A. Cytogenet. Cell Genet. (1995) [Pubmed]
  24. Microevolution and genetic affinities among six Amerindian tribes of lower Central America: comparative genetic study of serum proteins. Bieber, H., Bieber, S.W., Rodewald, A., Barrantes, R. Hum. Biol. (1996) [Pubmed]
  25. Latitude-correlated genetic polymorphisms: selection or gene flow? Ciminelli, B.M., Jodice, C., Scozzari, R., Corbo, R.M., Nahum, M., Pompei, F., Santachiara-Benerecetti, S.A., Santolamazza, C., Morpurgo, G.P., Modiano, G. Hum. Biol. (2000) [Pubmed]
  26. Isoelectric focusing studies in Brazilian Indians--uncovering variation of ORM, AHSG and IF. Salzano, F.M., Umetsu, K., Yuasa, I., Black, F.L., Suzuki, T. Jinrui Idengaku Zasshi (1990) [Pubmed]
  27. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. Osawa, M., Umetsu, K., Ohki, T., Nagasawa, T., Suzuki, T., Takeichi, S. Hum. Genet. (1997) [Pubmed]
  28. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). Osawa, M., Umetsu, K., Sato, M., Ohki, T., Yukawa, N., Suzuki, T., Takeichi, S. Gene (1997) [Pubmed]
  29. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. Osawa, M., Tian, W., Horiuchi, H., Kaneko, M., Umetsu, K. Hum. Genet. (2005) [Pubmed]
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