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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification.

Reciprocal gene activation and restriction during cell type differentiation from a common lineage is a hallmark of mammalian organogenesis. A key question, then, is whether a critical transcriptional activator of cell type-specific gene targets can also restrict expression of the same genes in other cell types. Here, we show that whereas the pituitary-specific POU domain factor Pit-1 activates growth hormone gene expression in one cell type, the somatotrope, it restricts its expression from a second cell type, the lactotrope. This distinction depends on a two-base pair spacing in accommodation of the bipartite POU domains on a conserved growth hormone promoter site. The allosteric effect on Pit-1, in combination with other DNA binding factors, results in the recruitment of a corepressor complex, including nuclear receptor corepressor N-CoR, which, unexpectedly, is required for active long-term repression of the growth hormone gene in lactotropes.[1]

References

  1. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Scully, K.M., Jacobson, E.M., Jepsen, K., Lunyak, V., Viadiu, H., Carrière, C., Rose, D.W., Hooshmand, F., Aggarwal, A.K., Rosenfeld, M.G. Science (2000) [Pubmed]
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