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Gene Review

Ncor1  -  nuclear receptor co-repressor 1

Mus musculus

Synonyms: 5730405M06Rik, A230020K14Rik, N-CoR, N-CoR1, Nuclear receptor corepressor 1, ...
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High impact information on Ncor1


Biological context of Ncor1

  • This order is determined by the inherent substrate specificity of HDAC3, and unexpectedly predicts the binding preference of N-CoR/SMRT for submaximally acetylated H4 tails [6].
  • In this study we investigated whether the nuclear receptor corepressor nuclear receptor interacting protein 1 (Nrip1)/RIP140, which is essential for ovulation, is also required for postovulatory events, leading to pregnancy and parturition [7].
  • The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression [8].

Anatomical context of Ncor1

  • Third, over-expression of full length NCoR and SMRT in the hypothalamus abolished T(3)-dependent repression of TRH-luciferase [9].
  • Second, in situ hybridization showed that NCoR and SMRT mRNA expression profiles in the paraventricular nucleus were distinct from that of TRH mRNA [9].
  • Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR) [8].

Associations of Ncor1 with chemical compounds


Physical interactions of Ncor1


Regulatory relationships of Ncor1


Other interactions of Ncor1


  1. The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility. White, R., Leonardsson, G., Rosewell, I., Ann Jacobs, M., Milligan, S., Parker, M. Nat. Med. (2000) [Pubmed]
  2. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Scully, K.M., Jacobson, E.M., Jepsen, K., Lunyak, V., Viadiu, H., Carrière, C., Rose, D.W., Hooshmand, F., Aggarwal, A.K., Rosenfeld, M.G. Science (2000) [Pubmed]
  3. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Beaudoin, G.M., Sisk, J.M., Coulombe, P.A., Thompson, C.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Ogawa, S., Lozach, J., Jepsen, K., Sawka-Verhelle, D., Perissi, V., Sasik, R., Rose, D.W., Johnson, R.S., Rosenfeld, M.G., Glass, C.K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Identification of a nuclear domain with deacetylase activity. Downes, M., Ordentlich, P., Kao, H.Y., Alvarez, J.G., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. Hartman, H.B., Yu, J., Alenghat, T., Ishizuka, T., Lazar, M.A. EMBO Rep. (2005) [Pubmed]
  7. Embryo transfer experiments and ovarian transplantation identify the ovary as the only site in which nuclear receptor interacting protein 1/RIP140 action is crucial for female fertility. Leonardsson, G., Jacobs, M.A., White, R., Jeffery, R., Poulsom, R., Milligan, S., Parker, M. Endocrinology (2002) [Pubmed]
  8. Hairless and wnt signaling: allies in epithelial stem cell differentiation. Thompson, C.C., Sisk, J.M., Beaudoin, G.M. Cell Cycle (2006) [Pubmed]
  9. Nuclear corepressor and silencing mediator of retinoic and thyroid hormone receptors corepressor expression is incompatible with T(3)-dependent TRH regulation. Becker, N., Seugnet, I., Guissouma, H., Dupre, S.M., Demeneix, B.A. Endocrinology (2001) [Pubmed]
  10. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. Yu, C., Markan, K., Temple, K.A., Deplewski, D., Brady, M.J., Cohen, R.N. J. Biol. Chem. (2005) [Pubmed]
  11. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Wagner, B.L., Valledor, A.F., Shao, G., Daige, C.L., Bischoff, E.D., Petrowski, M., Jepsen, K., Baek, S.H., Heyman, R.A., Rosenfeld, M.G., Schulman, I.G., Glass, C.K. Mol. Cell. Biol. (2003) [Pubmed]
  12. A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Wang, Y., Porter, W.W., Suh, N., Honda, T., Gribble, G.W., Leesnitzer, L.M., Plunket, K.D., Mangelsdorf, D.J., Blanchard, S.G., Willson, T.M., Sporn, M.B. Mol. Endocrinol. (2000) [Pubmed]
  13. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Seol, W., Choi, H.S., Moore, D.D. Mol. Endocrinol. (1995) [Pubmed]
  14. DNA binding and interaction with the nuclear receptor corepressor of thyroid hormone receptor are required for ligand-independent stimulation of the mouse preprothyrotropin-releasing hormone gene. Satoh, T., Monden, T., Ishizuka, T., Mitsuhashi, T., Yamada, M., Mori, M. Mol. Cell. Endocrinol. (1999) [Pubmed]
  15. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Wang, L., Hiebert, S.W. Oncogene (2001) [Pubmed]
  16. p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. Espinosa, L., Santos, S., Inglés-Esteve, J., Muñoz-Canoves, P., Bigas, A. J. Cell. Sci. (2002) [Pubmed]
  17. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Pascual, G., Fong, A.L., Ogawa, S., Gamliel, A., Li, A.C., Perissi, V., Rose, D.W., Willson, T.M., Rosenfeld, M.G., Glass, C.K. Nature (2005) [Pubmed]
  18. Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR). Berrevoets, C.A., Umar, A., Trapman, J., Brinkmann, A.O. Biochem. J. (2004) [Pubmed]
  19. Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. Ding, X., Staudinger, J.L. Biochem. Pharmacol. (2005) [Pubmed]
  20. Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. Skorija, K., Cox, M., Sisk, J.M., Dowd, D.R., MacDonald, P.N., Thompson, C.C., Demay, M.B. Mol. Endocrinol. (2005) [Pubmed]
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